Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.

TitleFifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.
Publication TypeJournal Article
Year of Publication2017
AuthorsHowson, JMM, Zhao, W, Barnes, DR, Ho, W-K, Young, R, Paul, DS, Waite, LL, Freitag, DF, Fauman, EB, Salfati, EL, Sun, BB, Eicher, JD, Johnson, AD, Sheu, WHH, Nielsen, SF, Lin, W-Y, Surendran, P, Mälarstig, A, Wilk, JB, Tybjærg-Hansen, A, Rasmussen, KL, Kamstrup, PR, Deloukas, P, Erdmann, J, Kathiresan, S, Samani, NJ, Schunkert, H, Watkins, H, Do, R, Rader, DJ, Johnson, JA, Hazen, SL, Quyyumi, AA, Spertus, JA, Pepine, CJ, Franceschini, N, Justice, A, Reiner, AP, Buyske, S, Hindorff, LA, Carty, CL, North, KE, Kooperberg, C, Boerwinkle, E, Young, K, Graff, M, Peters, U, Absher, D, Hsiung, CA, Lee, W-J, Taylor, KD, Chen, Y-H, Lee, I-T, Guo, X, Chung, R-H, Hung, Y-J, Rotter, JI, Juang, J-MJ, Quertermous, T, Wang, T-D, Rasheed, A, Frossard, P, Alam, DS, Majumder, AAl Shafi, Di Angelantonio, E, Chowdhury, iv, R, Chen, Y-DIda, Nordestgaard, BG, Assimes, TL, Danesh, J, Butterworth, AS, Saleheen, D
Corporate AuthorsCARDIoGRAMplusC4D, EPIC-CVD
JournalNat Genet
Volume49
Issue7
Pagination1113-1119
Date Published2017 Jul
ISSN1546-1718
KeywordsArteries, Atherosclerosis, Cell Adhesion, Chemotaxis, Leukocyte, Coronary Artery Disease, Energy Metabolism, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Histone Code, Humans, Male, Muscle, Smooth, Vascular, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Risk Factors
Abstract

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may be larger-scale evaluation of promising associations suggested by genome-wide association studies (GWAS). Hence, we genotyped 56,309 participants using a targeted gene array derived from earlier GWAS results and performed meta-analysis of results with 194,427 participants previously genotyped, totaling 88,192 CAD cases and 162,544 controls. We identified 25 new SNP-CAD associations (P

DOI10.1038/ng.3874
Alternate JournalNat. Genet.
PubMed ID28530674
PubMed Central IDPMC5555387
Grant ListK23 DK088942 / DK / NIDDK NIH HHS / United States
K99 HL130580 / HL / NHLBI NIH HHS / United States
R21 HL123677 / HL / NHLBI NIH HHS / United States
R56 DK104806 / DK / NIDDK NIH HHS / United States