| Title | FlyVar: a database for genetic variation in Drosophila melanogaster. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Wang, F, Jiang, L, Chen, Y, Haelterman, NA, Bellen, HJ, Chen, R |
| Journal | Database (Oxford) |
| Volume | 2015 |
| Date Published | 2015 |
| ISSN | 1758-0463 |
| Keywords | Animals, Databases, Genetic, Drosophila melanogaster, Genes, Insect, Molecular Sequence Annotation, Polymorphism, Genetic, User-Computer Interface |
| Abstract | FlyVar is a publicly and freely available platform that addresses the increasing need of next generation sequencing data analysis in the Drosophila research community. It is composed of three parts. First, a database that contains 5.94 million DNA polymorphisms found in Drosophila melanogaster derived from whole genome shotgun sequencing of 612 genomes of D. melanogaster. In addition, a list of 1094 dispensable genes has been identified. Second, a graphical user interface (GUI) has been implemented to allow easy and flexible queries of the database. Third, a set of interactive online tools enables filtering and annotation of genomic sequences obtained from individual D. melanogaster strains to identify candidate mutations. FlyVar permits the analysis of next generation sequencing data without the need of extensive computational training or resources. Database URL: www.iipl.fudan.edu.cn/FlyVar. |
| DOI | 10.1093/database/bav079 |
| Alternate Journal | Database (Oxford) |
| PubMed ID | 26289428 |
| PubMed Central ID | PMC4541374 |
| Grant List | 1RC4GM096355-01 / GM / NIGMS NIH HHS / United States |