FlyVar: a database for genetic variation in Drosophila melanogaster.

TitleFlyVar: a database for genetic variation in Drosophila melanogaster.
Publication TypeJournal Article
Year of Publication2015
AuthorsWang, F, Jiang, L, Chen, Y, Haelterman, NA, Bellen, HJ, Chen, R
JournalDatabase (Oxford)
Volume2015
Date Published2015
ISSN1758-0463
KeywordsAnimals, Databases, Genetic, Drosophila melanogaster, Genes, Insect, Molecular Sequence Annotation, Polymorphism, Genetic, User-Computer Interface
Abstract

FlyVar is a publicly and freely available platform that addresses the increasing need of next generation sequencing data analysis in the Drosophila research community. It is composed of three parts. First, a database that contains 5.94 million DNA polymorphisms found in Drosophila melanogaster derived from whole genome shotgun sequencing of 612 genomes of D. melanogaster. In addition, a list of 1094 dispensable genes has been identified. Second, a graphical user interface (GUI) has been implemented to allow easy and flexible queries of the database. Third, a set of interactive online tools enables filtering and annotation of genomic sequences obtained from individual D. melanogaster strains to identify candidate mutations. FlyVar permits the analysis of next generation sequencing data without the need of extensive computational training or resources. Database URL: www.iipl.fudan.edu.cn/FlyVar.

DOI10.1093/database/bav079
Alternate JournalDatabase (Oxford)
PubMed ID26289428
PubMed Central IDPMC4541374
Grant List1RC4GM096355-01 / GM / NIGMS NIH HHS / United States