Full disclosure: Genome assembly is still hard.

TitleFull disclosure: Genome assembly is still hard.
Publication TypeJournal Article
Year of Publication2018
AuthorsRichards, S
JournalPLoS Biol
Date Published2018 Apr
KeywordsAnimals, Desiccation, Genome, Genomics, Rotifera, Tardigrada

Two recent papers highlight the fascinating comparative genomics of anhydrobiosis, the ability to withstand complete desiccation, in bdelloid rotifers and tardigrades. However, both groups had to openly deal with the significant difficulties of generating and interpreting short-read draft assemblies-especially challenging in microscopic species with high sequence polymorphism. These exemplars demonstrate the need to go beyond single draft-quality reference genomes to high-quality multiple species comparative genomics if we are to fully capture the value of genomics.

Alternate JournalPLoS Biol
PubMed ID29689052
PubMed Central IDPMC5915270
Grant ListU54 HG003273 / HG / NHGRI NIH HHS / United States

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