G309D and W437OPA PINK1 mutations in Caucasian Parkinson's disease patients.

TitleG309D and W437OPA PINK1 mutations in Caucasian Parkinson's disease patients.
Publication TypeJournal Article
Year of Publication2005
AuthorsDeng, H, Le, WD, Zhang, X, Pan, TH, Jankovic, J
JournalActa Neurol Scand
Volume111
Issue6
Pagination351-2
Date Published2005 Jun
ISSN0001-6314
KeywordsAdult, Amino Acid Substitution, DNA Mutational Analysis, European Continental Ancestry Group, Female, Genetic Testing, Genome, Human, Humans, Male, Middle Aged, Mutation, Parkinson Disease, Protein Kinases, United States
Abstract

OBJECTIVE: To determine whether the G309D and W437OPA mutations in PINK1 gene are present in American Caucasian population of patients with Parkinson's disease (PD).METHODS: We searched for the G309D and W437OPA mutation by sequencing the regions of interest in the PINK1 gene in 237 unrelated Caucasian patients.RESULTS: None of the 237 samples showed the G309D or W437OPA mutations.CONCLUSIONS: The G309D and W437OPA mutations in PINK1 gene probably do not represent common causes of familial or sporadic PD in a Caucasian population.

DOI10.1111/j.1600-0404.2005.00383.x
Alternate JournalActa Neurol. Scand.
PubMed ID15876334
Grant List043567 / / PHS HHS / United States