| Title | G309D and W437OPA PINK1 mutations in Caucasian Parkinson's disease patients. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Deng, H, Le, WD, Zhang, X, Pan, TH, Jankovic, J |
| Journal | Acta Neurol Scand |
| Volume | 111 |
| Issue | 6 |
| Pagination | 351-2 |
| Date Published | 2005 Jun |
| ISSN | 0001-6314 |
| Keywords | Adult, Amino Acid Substitution, DNA Mutational Analysis, Female, Genetic Testing, Genome, Human, Humans, Male, Middle Aged, Mutation, Parkinson Disease, Protein Kinases, United States, White People |
| Abstract | OBJECTIVE: To determine whether the G309D and W437OPA mutations in PINK1 gene are present in American Caucasian population of patients with Parkinson's disease (PD).METHODS: We searched for the G309D and W437OPA mutation by sequencing the regions of interest in the PINK1 gene in 237 unrelated Caucasian patients.RESULTS: None of the 237 samples showed the G309D or W437OPA mutations.CONCLUSIONS: The G309D and W437OPA mutations in PINK1 gene probably do not represent common causes of familial or sporadic PD in a Caucasian population.
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| DOI | 10.1111/j.1600-0404.2005.00383.x |
| Alternate Journal | Acta Neurol Scand |
| PubMed ID | 15876334 |
| Grant List | 043567 / / PHS HHS / United States |