Gene content evolution in the arthropods.

 
TitleGene content evolution in the arthropods.
Publication TypeJournal Article
Year of Publication2020
AuthorsThomas, GWC, Dohmen, E, Hughes, DST, Murali, SC, Poelchau, M, Glastad, K, Anstead, CA, Ayoub, NA, Batterham, P, Bellair, M, Binford, GJ, Chao, H, Chen, YH, Childers, C, Dinh, H, Doddapaneni, H, Duan, JJ, Dugan, S, Esposito, LA, Friedrich, M, Garb, J, Gasser, RB, Goodisman, MAD, Gundersen-Rindal, DE, Han, Y, Handler, AM, Hatakeyama, M, Hering, L, Hunter, WB, Ioannidis, P, Jayaseelan, JC, Kalra, D, Khila, A, Korhonen, PK, Lee, CEunmi, Lee, SL, Li, Y, Lindsey, ARI, Mayer, G, McGregor, AP, McKenna, DD, Misof, B, Munidasa, M, Munoz-Torres, M, Muzny, DM, Niehuis, O, Osuji-Lacy, N, Palli, SR, Panfilio, KA, Pechmann, M, Perry, T, Peters, RS, Poynton, HC, Prpic, N-M, Qu, J, Rotenberg, D, Schal, C, Schoville, SD, Scully, ED, Skinner, E, Sloan, DB, Stouthamer, R, Strand, MR, Szucsich, NU, Wijeratne, A, Young, ND, Zattara, EE, Benoit, JB, Zdobnov, EM, Pfrender, ME, Hackett, KJ, Werren, JH, Worley, KC, Gibbs, RA, Chipman, AD, Waterhouse, RM, Bornberg-Bauer, E, Hahn, MW, Richards, S
JournalGenome Biol
Volume21
Issue1
Pagination15
Date Published2020 Jan 23
ISSN1474-760X
Abstract

BACKGROUND: Arthropods comprise the largest and most diverse phylum on Earth and play vital roles in nearly every ecosystem. Their diversity stems in part from variations on a conserved body plan, resulting from and recorded in adaptive changes in the genome. Dissection of the genomic record of sequence change enables broad questions regarding genome evolution to be addressed, even across hyper-diverse taxa within arthropods.

RESULTS: Using 76 whole genome sequences representing 21 orders spanning more than 500 million years of arthropod evolution, we document changes in gene and protein domain content and provide temporal and phylogenetic context for interpreting these innovations. We identify many novel gene families that arose early in the evolution of arthropods and during the diversification of insects into modern orders. We reveal unexpected variation in patterns of DNA methylation across arthropods and examples of gene family and protein domain evolution coincident with the appearance of notable phenotypic and physiological adaptations such as flight, metamorphosis, sociality, and chemoperception.

CONCLUSIONS: These analyses demonstrate how large-scale comparative genomics can provide broad new insights into the genotype to phenotype map and generate testable hypotheses about the evolution of animal diversity.

DOI10.1186/s13059-019-1925-7
Alternate JournalGenome Biol.
PubMed ID31969194
Grant ListU54 HG003273 / HG / NHGRI NIH HHS / United States
DBI-1564611 / / National Science Foundation /
1355169 / / National Science Foundation /
281125614 / GRK2220 / / Deutsche Forschungsgemeinschaft /
PP00P3_170664 / / Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung /
31003A_143936 / / Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung /
15-8130-0547-CA / / Agricultural Research Service /
NI 1387/3-1, MI 649/12-1 / / Deutsche Forschungsgemeinschaft /
NCHHU-0007-13 / / U.S. Department of Housing and Urban Development (US) /
1557864 / / National Science Foundation /
2013-5-35 MBE / / Alfred P. Sloan Foundation /