Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.

TitleGene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
Publication TypeJournal Article
Year of Publication2021
AuthorsFuentes, Lde Las, Sung, YJu, Noordam, R, Winkler, T, Feitosa, MF, Schwander, K, Bentley, AR, Brown, MR, Guo, X, Manning, A, Chasman, DI, Aschard, H, Bartz, TM, Bielak, LF, Campbell, A, Cheng, C-Y, Dorajoo, R, Hartwig, FP, Horimoto, ARVR, Li, C, Li-Gao, R, Liu, Y, Marten, J, Musani, SK, Ntalla, I, Rankinen, T, Richard, M, Sim, X, Smith, AV, Tajuddin, SM, Tayo, BO, Vojinovic, D, Warren, HR, Xuan, D, Alver, M, Boissel, M, Chai, J-F, Chen, X, Christensen, K, Divers, J, Evangelou, E, Gao, C, Girotto, G, Harris, SE, He, M, Hsu, F-C, Kühnel, B, Laguzzi, F, Li, X, Lyytikäinen, L-P, Nolte, IM, Poveda, A, Rauramaa, R, Riaz, M, Rueedi, R, Shu, X-O, Snieder, H, Sofer, T, Takeuchi, F, Verweij, N, Ware, EB, Weiss, S, Yanek, LR, Amin, N, Arking, DE, Arnett, DK, Bergmann, S, Boerwinkle, E, Brody, JA, Broeckel, U, Brumat, M, Burke, G, Cabrera, CP, Canouil, M, Chee, MLi, Chen, Y-DIda, Cocca, M, Connell, J, H de Silva, J, de Vries, PS, Eiriksdottir, G, Faul, JD, Fisher, V, Forrester, T, Fox, EF, Friedlander, Y, Gao, H, Gigante, B, Giulianini, F, Gu, CCharles, Gu, D, Harris, TB, He, J, Heikkinen, S, Heng, C-K, Hunt, S, M Ikram, A, Irvin, MR, Kähönen, M, Kavousi, M, Khor, CChuen, Kilpeläinen, TO, Koh, W-P, Komulainen, P, Kraja, AT, Krieger, JE, Langefeld, CD, Li, Y, Liang, J, Liewald, DCM, Liu, C-T, Liu, J, Lohman, KK, Mägi, R, McKenzie, CA, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mook-Kanamori, DO, Nalls, MA, Nelson, CP, Norris, JM, O'Connell, J, Ogunniyi, A, Padmanabhan, S, Palmer, ND, Pedersen, NL, Perls, T, Peters, A, Petersmann, A, Peyser, PA, Polasek, O, Porteous, DJ, Raffel, LJ, Rice, TK, Rotter, JI, Rudan, I, Rueda-Ochoa, O-L, Sabanayagam, C, Salako, BL, Schreiner, PJ, Shikany, JM, Sidney, SS, Sims, M, Sitlani, CM, Smith, JA, Starr, JM, Strauch, K, Swertz, MA, Teumer, A, Tham, YChung, Uitterlinden, AG, Vaidya, D, M van der Ende, Y, Waldenberger, M, Wang, L, Wang, Y-X, Bin Wei, W-, Weir, DR, Wen, W, Yao, J, Yu, B, Yu, C, Yuan, J-M, Zhao, W, Zonderman, AB, Becker, DM, Bowden, DW, Deary, IJ, Dörr, M, Esko, T, Freedman, BI, Froguel, P, Gasparini, P, Gieger, C, Jonas, JBruno, Kammerer, CM, Kato, N, Lakka, TA, Leander, K, Lehtimäki, T, Magnusson, PKE, Marques-Vidal, P, Penninx, BWJH, Samani, NJ, van der Harst, P, Wagenknecht, LE, Wu, T, Zheng, W, Zhu, X, Bouchard, C, Cooper, RS, Correa, A, Evans, MK, Gudnason, V, Hayward, C, Horta, BL, Kelly, TN, Kritchevsky, SB, Levy, D, Palmas, WR, Pereira, AC, Province, MM, Psaty, BM, Ridker, PM, Rotimi, CN, E Tai, S, van Dam, RM, van Duijn, CM, Wong, TYin, Rice, K, W Gauderman, J, Morrison, AC, North, KE, Kardia, SLR, Caulfield, MJ, Elliott, P, Munroe, PB, Franks, PW, Rao, DC, Fornage, M
Corporate AuthorsLifeLines Cohort Study
JournalMol Psychiatry
Volume26
Issue6
Pagination2111-2125
Date Published2021 Jun
ISSN1476-5578
KeywordsBlood Pressure, Epistasis, Genetic, Genetic Loci, Genome-Wide Association Study, Humans, Hypertension, Polymorphism, Single Nucleotide
Abstract

Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, "Some College" (yes/no) and "Graduated College" (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follow-up on promising variants in Stage 2 studies (N = 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P 

DOI10.1038/s41380-020-0719-3
Alternate JournalMol Psychiatry
PubMed ID32372009
PubMed Central IDPMC7641978
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RC2 MH089951 / MH / NIMH NIH HHS / United States
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