Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.

TitleGene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
Publication TypeJournal Article
Year of Publication2020
AuthorsFuentes, Lde Las, Sung, YJu, Noordam, R, Winkler, T, Feitosa, MF, Schwander, K, Bentley, AR, Brown, MR, Guo, X, Manning, A, Chasman, DI, Aschard, H, Bartz, TM, Bielak, LF, Campbell, A, Cheng, C-Y, Dorajoo, R, Hartwig, FP, Horimoto, ARVR, Li, C, Li-Gao, R, Liu, Y, Marten, J, Musani, SK, Ntalla, I, Rankinen, T, Richard, M, Sim, X, Smith, AV, Tajuddin, SM, Tayo, BO, Vojinovic, D, Warren, HR, Xuan, D, Alver, M, Boissel, M, Chai, J-F, Chen, X, Christensen, K, Divers, J, Evangelou, E, Gao, C, Girotto, G, Harris, SE, He, M, Hsu, F-C, Kühnel, B, Laguzzi, F, Li, X, Lyytikäinen, L-P, Nolte, IM, Poveda, A, Rauramaa, R, Riaz, M, Rueedi, R, Shu, X-O, Snieder, H, Sofer, T, Takeuchi, F, Verweij, N, Ware, EB, Weiss, S, Yanek, LR, Amin, N, Arking, DE, Arnett, DK, Bergmann, S, Boerwinkle, E, Brody, JA, Broeckel, U, Brumat, M, Burke, G, Cabrera, CP, Canouil, M, Chee, MLi, Chen, Y-DIda, Cocca, M, Connell, J, H de Silva, J, de Vries, PS, Eiriksdottir, G, Faul, JD, Fisher, V, Forrester, T, Fox, EF, Friedlander, Y, Gao, H, Gigante, B, Giulianini, F, Gu, CCharles, Gu, D, Harris, TB, He, J, Heikkinen, S, Heng, C-K, Hunt, S, M Ikram, A, Irvin, MR, Kähönen, M, Kavousi, M, Khor, CChuen, Kilpeläinen, TO, Koh, W-P, Komulainen, P, Kraja, AT, Krieger, JE, Langefeld, CD, Li, Y, Liang, J, Liewald, DCM, Liu, C-T, Liu, J, Lohman, KK, Mägi, R, McKenzie, CA, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mook-Kanamori, DO, Nalls, MA, Nelson, CP, Norris, JM, O'Connell, J, Ogunniyi, A, Padmanabhan, S, Palmer, ND, Pedersen, NL, Perls, T, Peters, A, Petersmann, A, Peyser, PA, Polasek, O, Porteous, DJ, Raffel, LJ, Rice, TK, Rotter, JI, Rudan, I, Rueda-Ochoa, O-L, Sabanayagam, C, Salako, BL, Schreiner, PJ, Shikany, JM, Sidney, SS, Sims, M, Sitlani, CM, Smith, JA, Starr, JM, Strauch, K, Swertz, MA, Teumer, A, Tham, YChung, Uitterlinden, AG, Vaidya, D, M van der Ende, Y, Waldenberger, M, Wang, L, Wang, Y-X, Bin Wei, W-, Weir, DR, Wen, W, Yao, J, Yu, B, Yu, C, Yuan, J-M, Zhao, W, Zonderman, AB, Becker, DM, Bowden, DW, Deary, IJ, Dörr, M, Esko, T, Freedman, BI, Froguel, P, Gasparini, P, Gieger, C, Jonas, JBruno, Kammerer, CM, Kato, N, Lakka, TA, Leander, K, Lehtimäki, T, Magnusson, PKE, Marques-Vidal, P, Penninx, BWJH, Samani, NJ, van der Harst, P, Wagenknecht, LE, Wu, T, Zheng, W, Zhu, X, Bouchard, C, Cooper, RS, Correa, A, Evans, MK, Gudnason, V, Hayward, C, Horta, BL, Kelly, TN, Kritchevsky, SB, Levy, D, Palmas, WR, Pereira, AC, Province, MM, Psaty, BM, Ridker, PM, Rotimi, CN, E Tai, S, van Dam, RM, van Duijn, CM, Wong, TYin, Rice, K, W Gauderman, J, Morrison, AC, North, KE, Kardia, SLR, Caulfield, MJ, Elliott, P, Munroe, PB, Franks, PW, Rao, DC, Fornage, M
Corporate AuthorsLifeLines Cohort Study
JournalMol Psychiatry
Date Published2020 May 05
ISSN1476-5578
Abstract

Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, "Some College" (yes/no) and "Graduated College" (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follow-up on promising variants in Stage 2 studies (N = 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P 

DOI10.1038/s41380-020-0719-3
Alternate JournalMol. Psychiatry
PubMed ID32372009
Grant ListR01 DK085175 / DK / NIDDK NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
NNF17OC0026848 / / Novo Nordisk Fonden (Novo Nordisk Foundation) /
U01 HL130114 / HL / NHLBI NIH HHS / United States
R01 DK089256 / DK / NIDDK NIH HHS / United States
R01HL118305 / / U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) /
UM1 CA182913 / CA / NCI NIH HHS / United States
R01 CA047988 / CA / NCI NIH HHS / United States
U01 AG052409 / AG / NIA NIH HHS / United States