|Title||Gene Expression Profiles in Cancers and Their Therapeutic Implications.|
|Publication Type||Journal Article|
|Year of Publication||2023|
|Date Published||2023 Jan-Feb 01|
|Keywords||Breast Neoplasms, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Neoplasms, Transcriptome|
The vast amount of gene expression profiling data of bulk tumors and cell lines available in the public domain represents a tremendous resource. For any major cancer type, expression data can identify molecular subtypes, predict patient outcome, identify markers of therapeutic response, determine the functional consequences of somatic mutation, and elucidate the biology of metastatic and advanced cancers. This review provides a broad overview of gene expression profiling in cancer (which may include transcriptome and proteome levels) and the types of findings made using these data. This review also provides specific examples of accessing public cancer gene expression data sets and generating unique views of the data and the resulting genes of interest. These examples involve pan-cancer molecular subtyping, metabolism-associated expression correlates of patient survival involving multiple cancer types, and gene expression correlates of chemotherapy response in breast tumors.
|Alternate Journal||Cancer J|
|PubMed Central ID||PMC9881750|
|Grant List||P30 CA125123 / CA / NCI NIH HHS / United States|
Gene Expression Profiles in Cancers and Their Therapeutic Implications.
|Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality. Nat Commun. 2023;14(1):6113..|
|PLS3 missense variants affecting the actin-binding domains cause X-linked congenital diaphragmatic hernia and body-wall defects. Am J Hum Genet. 2023;110(10):1787-1803..|
|Chimeric RNAs reveal putative neoantigen peptides for developing tumor vaccines for breast cancer. Front Immunol. 2023;14:1188831..|