Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

TitleGenetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Publication TypeJournal Article
Year of Publication2018
AuthorsEvangelou, E, Warren, HR, Mosen-Ansorena, D, Mifsud, B, Pazoki, R, Gao, H, Ntritsos, G, Dimou, N, Cabrera, CP, Karaman, I, Ng, FLiang, Evangelou, M, Witkowska, K, Tzanis, E, Hellwege, JN, Giri, A, Edwards, DRVelez, Sun, YV, Cho, K, J Gaziano, M, Wilson, PWF, Tsao, PS, Kovesdy, CP, Esko, T, Mägi, R, Milani, L, Almgren, P, Boutin, T, Debette, S, Ding, J, Giulianini, F, Holliday, EG, Jackson, AU, Li-Gao, R, Lin, W-Y, Luan, J'an, Mangino, M, Oldmeadow, C, Prins, BPeter, Qian, Y, Sargurupremraj, M, Shah, N, Surendran, P, Thériault, S, Verweij, N, Willems, SM, Zhao, J-H, Amouyel, P, Connell, J, de Mutsert, R, Doney, ASF, Farrall, M, Menni, C, Morris, AD, Noordam, R, Paré, G, Poulter, NR, Shields, DC, Stanton, A, Thom, S, Abecasis, G, Amin, N, Arking, DE, Ayers, KL, Barbieri, CM, Batini, C, Bis, JC, Blake, T, Bochud, M, Boehnke, M, Boerwinkle, E, Boomsma, DI, Bottinger, EP, Braund, PS, Brumat, M, Campbell, A, Campbell, H, Chakravarti, A, Chambers, JC, Chauhan, G, Ciullo, M, Cocca, M, Collins, F, Cordell, HJ, Davies, G, de Borst, MH, de Geus, EJ, Deary, IJ, Deelen, J, M, FDel Greco, Demirkale, CYusuf, Dörr, M, Ehret, GB, Elosua, R, Enroth, S, A Erzurumluoglu, M, Ferreira, T, Frånberg, M, Franco, OH, Gandin, I, Gasparini, P, Giedraitis, V, Gieger, C, Girotto, G, Goel, A, Gow, AJ, Gudnason, V, Guo, X, Gyllensten, U, Hamsten, A, Harris, TB, Harris, SE, Hartman, CA, Havulinna, AS, Hicks, AA, Hofer, E, Hofman, A, Hottenga, J-J, Huffman, JE, Hwang, S-J, Ingelsson, E, James, A, Jansen, R, Jarvelin, M-R, Joehanes, R, Johansson, Å, Johnson, AD, Joshi, PK, Jousilahti, P, J Jukema, W, Jula, A, Kähönen, M, Kathiresan, S, Keavney, BD, Khaw, K-T, Knekt, P, Knight, J, Kolcic, I, Kooner, JS, Koskinen, S, Kristiansson, K, Kutalik, Z, Laan, M, Larson, M, Launer, LJ, Lehne, B, Lehtimäki, T, Liewald, DCM, Lin, L, Lind, L, Lindgren, CM, Liu, Y, Loos, RJF, Lopez, LM, Lu, Y, Lyytikäinen, L-P, Mahajan, A, Mamasoula, C, Marrugat, J, Marten, J, Milaneschi, Y, Morgan, A, Morris, AP, Morrison, AC, Munson, PJ, Nalls, MA, Nandakumar, P, Nelson, CP, Niiranen, T, Nolte, IM, Nutile, T, Oldehinkel, AJ, Oostra, BA, O'Reilly, PF, Org, E, Padmanabhan, S, Palmas, W, Palotie, A, Pattie, A, Penninx, BWJH, Perola, M, Peters, A, Polasek, O, Pramstaller, PP, Nguyen, QTri, Raitakari, OT, Ren, M, Rettig, R, Rice, K, Ridker, PM, Ried, JS, Riese, H, Ripatti, S, Robino, A, Rose, LM, Rotter, JI, Rudan, I, Ruggiero, D, Saba, Y, Sala, CF, Salomaa, V, Samani, NJ, Sarin, A-P, Schmidt, R, Schmidt, H, Shrine, N, Siscovick, D, Smith, AV, Snieder, H, Sõber, S, Sorice, R, Starr, JM, Stott, DJ, Strachan, DP, Strawbridge, RJ, Sundström, J, Swertz, MA, Taylor, KD, Teumer, A, Tobin, MD, Tomaszewski, M, Toniolo, D, Traglia, M, Trompet, S, Tuomilehto, J, Tzourio, C, Uitterlinden, AG, Vaez, A, van der Most, PJ, van Duijn, CM, Vergnaud, A-C, Verwoert, GC, Vitart, V, Völker, U, Vollenweider, P, Vuckovic, D, Watkins, H, Wild, SH, Willemsen, G, Wilson, JF, Wright, AF, Yao, J, Zemunik, T, Zhang, W, Attia, JR, Butterworth, AS, Chasman, DI, Conen, D, Cucca, F, Danesh, J, Hayward, C, Howson, JMM, Laakso, M, Lakatta, EG, Langenberg, C, Melander, O, Mook-Kanamori, DO, Palmer, CNA, Risch, L, Scott, RA, Scott, RJ, Sever, P, Spector, TD, van der Harst, P, Wareham, NJ, Zeggini, E, Levy, D, Munroe, PB, Newton-Cheh, C, Brown, MJ, Metspalu, A, Hung, AM, O'Donnell, CJ, Edwards, TL, Psaty, BM, Tzoulaki, I, Barnes, MR, Wain, LV, Elliott, P, Caulfield, MJ
Corporate AuthorsMillion Veteran Program
JournalNat Genet
Volume50
Issue10
Pagination1412-1425
Date Published2018 Oct
ISSN1546-1718
KeywordsAdult, Aged, Aged, 80 and over, Blood Pressure, Cardiovascular Diseases, Cells, Cultured, Female, Genetic Loci, Genetic Predisposition to Disease, Genetic Testing, Genetics, Population, Genome-Wide Association Study, Human Umbilical Vein Endothelial Cells, Humans, Hypertension, Life Style, Male, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Risk Factors
Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
DOI10.1038/s41588-018-0205-x
Alternate JournalNat Genet
PubMed ID30224653
PubMed Central IDPMC6284793
Grant ListMR/L003120/1 / MRC_ / Medical Research Council / United Kingdom
U01 HL130114 / HL / NHLBI NIH HHS / United States
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
MR/K007017/1 / MRC_ / Medical Research Council / United Kingdom
RG/08/014/24067 / BHF_ / British Heart Foundation / United Kingdom
M01 RR000070 / RR / NCRR NIH HHS / United States
U01 DK102163 / DK / NIDDK NIH HHS / United States
BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
FS/12/82/29736 / BHF_ / British Heart Foundation / United Kingdom
U01 HG007417 / HG / NHGRI NIH HHS / United States
SP/13/2/30111 / BHF_ / British Heart Foundation / United Kingdom
MC_UU_12015/7 / MRC_ / Medical Research Council / United Kingdom
R01 HL120393 / HL / NHLBI NIH HHS / United States
RG/13/13/30194 / BHF_ / British Heart Foundation / United Kingdom
MR/M501633/1 / MRC_ / Medical Research Council / United Kingdom
U01 HL120393 / HL / NHLBI NIH HHS / United States
T32 CA160056 / CA / NCI NIH HHS / United States
MR/N01104X/2 / MRC_ / Medical Research Council / United Kingdom
R01 HL086694 / HL / NHLBI NIH HHS / United States
R01 DK110113 / DK / NIDDK NIH HHS / United States
G1001799 / MRC_ / Medical Research Council / United Kingdom
MR/N003284/1 / MRC_ / Medical Research Council / United Kingdom
MC_PC_13040 / MRC_ / Medical Research Council / United Kingdom
R01 DK107786 / DK / NIDDK NIH HHS / United States
MR/S003061/1 / MRC_ / Medical Research Council / United Kingdom
MR/L01341X/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK075787 / DK / NIDDK NIH HHS / United States
MR/M004422/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK062370 / DK / NIDDK NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom
MR/L016311/1 / MRC_ / Medical Research Council / United Kingdom
MC_UU_12015/2 / MRC_ / Medical Research Council / United Kingdom
MR/N01104X/1 / MRC_ / Medical Research Council / United Kingdom
MR/N015746/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK101855 / DK / NIDDK NIH HHS / United States
MR/S003746/1 / MRC_ / Medical Research Council / United Kingdom
G0401527 / MRC_ / Medical Research Council / United Kingdom
MC_PC_U127561128 / MRC_ / Medical Research Council / United Kingdom
RG/15/12/31616 / BHF_ / British Heart Foundation / United Kingdom
G1000143 / MRC_ / Medical Research Council / United Kingdom
MR/L01632X/1 / MRC_ / Medical Research Council / United Kingdom
S10 OD023680 / OD / NIH HHS / United States
U01 HL137162 / HL / NHLBI NIH HHS / United States
I01 CX000982 / CX / CSRD VA / United States
MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom
U01 DK062370 / DK / NIDDK NIH HHS / United States
K12 HD043483 / HD / NICHD NIH HHS / United States
G0601966 / MRC_ / Medical Research Council / United Kingdom
14136 / CRUK_ / Cancer Research UK / United Kingdom
I01 BX003360 / BX / BLRD VA / United States
P30 DK020572 / DK / NIDDK NIH HHS / United States
/ WT_ / Wellcome Trust / United Kingdom
R21 HL121429 / HL / NHLBI NIH HHS / United States
MC_UU_12015/5 / MRC_ / Medical Research Council / United Kingdom

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