Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

TitleGenetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Publication TypeJournal Article
Year of Publication2018
AuthorsEvangelou, E, Warren, HR, Mosen-Ansorena, D, Mifsud, B, Pazoki, R, Gao, H, Ntritsos, G, Dimou, N, Cabrera, CP, Karaman, I, Ng, FLiang, Evangelou, M, Witkowska, K, Tzanis, E, Hellwege, JN, Giri, A, Edwards, DRVelez, Sun, YV, Cho, K, J Gaziano, M, Wilson, PWF, Tsao, PS, Kovesdy, CP, Esko, T, Mägi, R, Milani, L, Almgren, P, Boutin, T, Debette, S, Ding, J, Giulianini, F, Holliday, EG, Jackson, AU, Li-Gao, R, Lin, W-Y, Luan, J'an, Mangino, M, Oldmeadow, C, Prins, BPeter, Qian, Y, Sargurupremraj, M, Shah, N, Surendran, P, Thériault, S, Verweij, N, Willems, SM, Zhao, J-H, Amouyel, P, Connell, J, de Mutsert, R, Doney, ASF, Farrall, M, Menni, C, Morris, AD, Noordam, R, Paré, G, Poulter, NR, Shields, DC, Stanton, A, Thom, S, Abecasis, G, Amin, N, Arking, DE, Ayers, KL, Barbieri, CM, Batini, C, Bis, JC, Blake, T, Bochud, M, Boehnke, M, Boerwinkle, E, Boomsma, DI, Bottinger, EP, Braund, PS, Brumat, M, Campbell, A, Campbell, H, Chakravarti, A, Chambers, JC, Chauhan, G, Ciullo, M, Cocca, M, Collins, F, Cordell, HJ, Davies, G, de Borst, MH, de Geus, EJ, Deary, IJ, Deelen, J, M, FDel Greco, Demirkale, CYusuf, Dörr, M, Ehret, GB, Elosua, R, Enroth, S, A Erzurumluoglu, M, Ferreira, T, Frånberg, M, Franco, OH, Gandin, I, Gasparini, P, Giedraitis, V, Gieger, C, Girotto, G, Goel, A, Gow, AJ, Gudnason, V, Guo, X, Gyllensten, U, Hamsten, A, Harris, TB, Harris, SE, Hartman, CA, Havulinna, AS, Hicks, AA, Hofer, E, Hofman, A, Hottenga, J-J, Huffman, JE, Hwang, S-J, Ingelsson, E, James, A, Jansen, R, Jarvelin, M-R, Joehanes, R, Johansson, Å, Johnson, AD, Joshi, PK, Jousilahti, P, J Jukema, W, Jula, A, Kähönen, M, Kathiresan, S, Keavney, BD, Khaw, K-T, Knekt, P, Knight, J, Kolcic, I, Kooner, JS, Koskinen, S, Kristiansson, K, Kutalik, Z, Laan, M, Larson, M, Launer, LJ, Lehne, B, Lehtimäki, T, Liewald, DCM, Lin, L, Lind, L, Lindgren, CM, Liu, Y, Loos, RJF, Lopez, LM, Lu, Y, Lyytikäinen, L-P, Mahajan, A, Mamasoula, C, Marrugat, J, Marten, J, Milaneschi, Y, Morgan, A, Morris, AP, Morrison, AC, Munson, PJ, Nalls, MA, Nandakumar, P, Nelson, CP, Niiranen, T, Nolte, IM, Nutile, T, Oldehinkel, AJ, Oostra, BA, O'Reilly, PF, Org, E, Padmanabhan, S, Palmas, W, Palotie, A, Pattie, A, Penninx, BWJH, Perola, M, Peters, A, Polasek, O, Pramstaller, PP, Nguyen, QTri, Raitakari, OT, Ren, M, Rettig, R, Rice, K, Ridker, PM, Ried, JS, Riese, H, Ripatti, S, Robino, A, Rose, LM, Rotter, JI, Rudan, I, Ruggiero, D, Saba, Y, Sala, CF, Salomaa, V, Samani, NJ, Sarin, A-P, Schmidt, R, Schmidt, H, Shrine, N, Siscovick, D, Smith, AV, Snieder, H, Sõber, S, Sorice, R, Starr, JM, Stott, DJ, Strachan, DP, Strawbridge, RJ, Sundström, J, Swertz, MA, Taylor, KD, Teumer, A, Tobin, MD, Tomaszewski, M, Toniolo, D, Traglia, M, Trompet, S, Tuomilehto, J, Tzourio, C, Uitterlinden, AG, Vaez, A, van der Most, PJ, van Duijn, CM, Vergnaud, A-C, Verwoert, GC, Vitart, V, Völker, U, Vollenweider, P, Vuckovic, D, Watkins, H, Wild, SH, Willemsen, G, Wilson, JF, Wright, AF, Yao, J, Zemunik, T, Zhang, W, Attia, JR, Butterworth, AS, Chasman, DI, Conen, D, Cucca, F, Danesh, J, Hayward, C, Howson, JMM, Laakso, M, Lakatta, EG, Langenberg, C, Melander, O, Mook-Kanamori, DO, Palmer, CNA, Risch, L, Scott, RA, Scott, RJ, Sever, P, Spector, TD, van der Harst, P, Wareham, NJ, Zeggini, E, Levy, D, Munroe, PB, Newton-Cheh, C, Brown, MJ, Metspalu, A, Hung, AM, O'Donnell, CJ, Edwards, TL, Psaty, BM, Tzoulaki, I, Barnes, MR, Wain, LV, Elliott, P, Caulfield, MJ
Corporate Authors
JournalNat Genet
Volume50
Issue10
Pagination1412-1425
Date Published2018 Oct
ISSN1546-1718
Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

DOI10.1038/s41588-018-0205-x
Alternate JournalNat. Genet.
PubMed ID30224653
PubMed Central IDPMC6284793
Grant ListU01 HG007417 / HG / NHGRI NIH HHS / United States
SP/13/2/30111 / / British Heart Foundation / United Kingdom
T32 CA160056 / CA / NCI NIH HHS / United States
MR/L01632X/1 / / Medical Research Council / United Kingdom
R01 DK110113 / DK / NIDDK NIH HHS / United States
R01 DK107786 / DK / NIDDK NIH HHS / United States
MR/L01341X/1 / / Medical Research Council / United Kingdom
G0601966 / / Medical Research Council / United Kingdom
MC_UU_12015/1 / / Medical Research Council / United Kingdom
R01 DK062370 / DK / NIDDK NIH HHS / United States
R01 DK101855 / DK / NIDDK NIH HHS / United States
I01 CX000982 / CX / CSRD VA / United States
I01 BX003360 / BX / BLRD VA / United States
/ / Wellcome Trust / United Kingdom
R21 HL121429 / HL / NHLBI NIH HHS / United States
M01 RR000070 / RR / NCRR NIH HHS / United States
U01 DK102163 / DK / NIDDK NIH HHS / United States