Genetic contributions to the midsagittal area of the corpus callosum.

TitleGenetic contributions to the midsagittal area of the corpus callosum.
Publication TypeJournal Article
Year of Publication2012
AuthorsPhillips, KA, Rogers, J, Barrett, EA, Glahn, DC, Kochunov, P
JournalTwin Res Hum Genet
Date Published2012 Jun
KeywordsAnimals, Corpus Callosum, Female, Gene-Environment Interaction, Magnetic Resonance Imaging, Male, Organ Size, Papio, Quantitative Trait, Heritable

The degree to which genes and environment determine variations in brain structure and function is fundamentally important to understanding normal and disease-related patterns of neural organization and activity. We studied genetic contributions to the midsagittal area of the corpus callosum (CC) in pedigreed baboons (68 males, 112 females) to replicate findings of high genetic contribution to that area of the CC reported in humans, and to determine if the heritability of the CC midsagittal area in adults was modulated by fetal development rate. Measurements of callosal area were obtained from high-resolution MRI scans. Heritability was estimated from pedigree-based maximum likelihood estimation of genetic and non-genetic variance components as implemented in Sequential Oligogenic Linkage Analysis Routines (SOLAR). Our analyses revealed significant heritability for the total area of the CC and all of its subdivisions, with h2 = .46 for the total CC, and h2 = .54, .37, .62, .56, and .29 for genu, anterior midbody, medial midbody, posterior midbody and splenium, respectively. Genetic correlation analysis demonstrated that the individual subdivisions shared between 41% and 98% of genetic variability. Combined with previous research reporting high heritability of other brain structures in baboons, these results reveal a consistent pattern of high heritability for brain morphometric measures in baboons.

Alternate JournalTwin Res Hum Genet
PubMed ID22856367
PubMed Central IDPMC3474979
Grant ListP51 OD13986 / OD / NIH HHS / United States
R15 NS070717 / NS / NINDS NIH HHS / United States
K01 EB006395 / EB / NIBIB NIH HHS / United States
P51 OD011133 / OD / NIH HHS / United States
P51 RR013986 / RR / NCRR NIH HHS / United States

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