Genetic linkage and imprinting effects on body mass index in children and young adults.

TitleGenetic linkage and imprinting effects on body mass index in children and young adults.
Publication TypeJournal Article
Year of Publication2003
AuthorsGorlova, OY, Amos, CI, Wang, NW, Shete, S, Turner, ST, Boerwinkle, E
JournalEur J Hum Genet
Volume11
Issue6
Pagination425-32
Date Published2003 Jun
ISSN1018-4813
KeywordsAdolescent, Adult, Age Factors, Body Mass Index, Child, Child, Preschool, Chromosomes, Human, Pair 16, Chromosomes, Human, Pair 20, Genetic Linkage, Genomic Imprinting, Humans, Models, Genetic
Abstract

Body mass index (BMI) is used as a measure of fatness. Here we performed a genome-wide scan for genes related to BMI, while allowing for the possible effects of imprinting. We applied a sib pair linkage analysis to a sample of primarily children and young adults by using the Haseman-Elston method, which we modified to model the separate effects of paternally and maternally derived genetic factors. After stratification of sib pairs according to age, a number of regions showing linkage with BMI were identified. Most linkage and imprinting effects were found in children 5-11 years of age. Strongest evidences for linkage in children were found on chromosome 20 at 20p11.2-pter near the marker D20S851 (LOD(Total)=4.08, P=0.000046) and near the marker D20S482 (LOD(Total) =3.55, P=0.00016), and Chromosome 16 at 16p13 near the marker ATA41E04 (LOD(Total) =3.12, P=0.00025), and those loci did not show significant evidence for imprinting. Six regions showing evidence of imprinting were 3p23-p24 (paternal expression), 4q31.1-q32 (maternal expression), 10p14-q11 (paternal expression), and 12p12-pter (paternal expression) in children, and 4q31-qter (paternal expression) and 8p (paternal expression) in adults.

DOI10.1038/sj.ejhg.5200979
Alternate JournalEur. J. Hum. Genet.
PubMed ID12774034
Grant ListES09912 / ES / NIEHS NIH HHS / United States
HG02275 / HG / NHGRI NIH HHS / United States
HL51021 / HL / NHLBI NIH HHS / United States