The genetic structure of mouse ornithine transcarbamylase.

TitleThe genetic structure of mouse ornithine transcarbamylase.
Publication TypeJournal Article
Year of Publication1988
AuthorsScherer, SE, Veres, G, Caskey, CT
JournalNucleic Acids Res
Volume16
Issue4
Pagination1593-601
Date Published1988 Feb 25
ISSN0305-1048
KeywordsAnimals, Base Sequence, DNA Restriction Enzymes, DNA, Recombinant, Genes, Mice, Molecular Sequence Data, Nucleic Acid Hybridization, Ornithine Carbamoyltransferase
Abstract

The gene encoding the mouse urea cycle enzyme, ornithine transcarbamylase has been isolated on five partially overlapping bacteriophage lambda clones. We have characterized the gene and found that it is split between ten exons distributed over approximately 70 kb of the X chromosome. The introns range in size from 88 bases to the relatively unusual size of approximately 26 kilobases, while the splice donor/splice acceptor sequences conform to the consensus established for other eukaryotic genes.

Alternate JournalNucleic Acids Res.
PubMed ID2831503
PubMed Central IDPMC336337
Grant ListHD21452 / HD / NICHD NIH HHS / United States