Title | Genetic susceptibility, obesity and lifetime risk of type 2 diabetes: The ARIC study and Rotterdam Study. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Ligthart, S, Hasbani, NR, Ahmadizar, F, van Herpt, TTW, Leening, MJG, Uitterlinden, AG, Sijbrands, EJG, Morrison, AC, Boerwinkle, E, Pankow, JS, Selvin, E, M Ikram, A, Kavousi, M, de Vries, PS, Dehghan, A |
Journal | Diabet Med |
Volume | 38 |
Issue | 10 |
Pagination | e14639 |
Date Published | 2021 Oct |
ISSN | 1464-5491 |
Keywords | Aged, Diabetes Mellitus, Type 2, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Life Style, Male, Middle Aged, Multifactorial Inheritance, Obesity, Risk, White People |
Abstract | AIMS: Both lifestyle factors and genetic background contribute to the development of type 2 diabetes. Estimation of the lifetime risk of diabetes based on genetic information has not been presented, and the extent to which a normal body weight can offset a high lifetime genetic risk is unknown. METHODS: We used data from 15,671 diabetes-free participants of European ancestry aged 45 years and older from the prospective population-based ARIC study and Rotterdam Study (RS). We quantified the remaining lifetime risk of diabetes stratified by genetic risk and quantified the effect of normal weight in terms of relative and lifetime risks in low, intermediate and high genetic risk. RESULTS: At age 45 years, the lifetime risk of type 2 diabetes in ARIC in the low, intermediate and high genetic risk category was 33.2%, 41.3% and 47.2%, and in RS 22.8%, 30.6% and 35.5% respectively. The absolute lifetime risk for individuals with normal weight compared to individuals with obesity was 24% lower in ARIC and 8.6% lower in RS in the low genetic risk group, 36.3% lower in ARIC and 31.3% lower in RS in the intermediate genetic risk group, and 25.0% lower in ARIC and 29.4% lower in RS in the high genetic risk group. CONCLUSIONS: Genetic variants for type 2 diabetes have value in estimating the lifetime risk of type 2 diabetes. Normal weight mitigates partly the deleterious effect of high genetic risk. |
DOI | 10.1111/dme.14639 |
Alternate Journal | Diabet Med |
PubMed ID | 34245042 |
PubMed Central ID | PMC8429251 |
Grant List | UL1 RR025005 / RR / NCRR NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States P30 ES030285 / ES / NIEHS NIH HHS / United States K24 DK106414 / DK / NIDDK NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States UL1 TR003098 / TR / NCATS NIH HHS / United States R01 DK089174 / DK / NIDDK NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States |
Genetic susceptibility, obesity and lifetime risk of type 2 diabetes: The ARIC study and Rotterdam Study.
Similar Publications
DNA Methylation-Derived Immune Cell Proportions and Cancer Risk in Black Participants. Cancer Res Commun. 2024;4(10):2714-2723. | .
Whole genomes of Amazonian uakari monkeys reveal complex connectivity and fast differentiation driven by high environmental dynamism. Commun Biol. 2024;7(1):1283. | .
Identification of allele-specific KIV-2 repeats and impact on Lp(a) measurements for cardiovascular disease risk. BMC Med Genomics. 2024;17(1):255. | .