Genetic testing in ambulatory cardiology clinics reveals high rate of findings with clinical management implications.

TitleGenetic testing in ambulatory cardiology clinics reveals high rate of findings with clinical management implications.
Publication TypeJournal Article
Year of Publication2021
AuthorsMurdock, DR, Venner, E, Muzny, DM, Metcalf, GA, Murugan, M, Hadley, TD, Chander, V, de Vries, PS, Jia, X, Hussain, A, Agha, AM, Sabo, A, Li, S, Meng, Q, Hu, J, Tian, X, Cohen, M, Yi, V, Kovar, CL, Gingras, M-C, Korchina, V, Howard, C, Riconda, DL, Pereira, S, Smith, HS, Huda, ZA, Buentello, A, Marino, PR, Leiber, L, Balasubramanyam, A, Amos, CI, Civitello, AB, Chelu, MG, Maag, R, McGuire, AL, Boerwinkle, E, Wehrens, XHT, Ballantyne, CM, Gibbs, RA
JournalGenet Med
Volume23
Issue12
Pagination2404-2414
Date Published2021 12
ISSN1530-0366
KeywordsAdult, Cardiology, Cardiovascular Diseases, Genetic Testing, Humans, Pharmacogenetics, Pharmacogenomic Testing, United States
Abstract

PURPOSE: Cardiovascular disease (CVD) is the leading cause of death in adults in the United States, yet the benefits of genetic testing are not universally accepted.

METHODS: We developed the "HeartCare" panel of genes associated with CVD, evaluating high-penetrance Mendelian conditions, coronary artery disease (CAD) polygenic risk, LPA gene polymorphisms, and specific pharmacogenetic (PGx) variants. We enrolled 709 individuals from cardiology clinics at Baylor College of Medicine, and samples were analyzed in a CAP/CLIA-certified laboratory. Results were returned to the ordering physician and uploaded to the electronic medical record.

RESULTS: Notably, 32% of patients had a genetic finding with clinical management implications, even after excluding PGx results, including 9% who were molecularly diagnosed with a Mendelian condition. Among surveyed physicians, 84% reported medical management changes based on these results, including specialist referrals, cardiac tests, and medication changes. LPA polymorphisms and high polygenic risk of CAD were found in 20% and 9% of patients, respectively, leading to diet, lifestyle, and other changes. Warfarin and simvastatin pharmacogenetic variants were present in roughly half of the cohort.

CONCLUSION: Our results support the use of genetic information in routine cardiovascular health management and provide a roadmap for accompanying research.

DOI10.1038/s41436-021-01294-8
Alternate JournalGenet Med
PubMed ID34363016
PubMed Central IDPMC8931845
Grant ListR01 HL146860 / HL / NHLBI NIH HHS / United States