Genome scale identification of Treponema pallidum antigens.

TitleGenome scale identification of Treponema pallidum antigens.
Publication TypeJournal Article
Year of Publication2005
AuthorsMcKevitt, M, Brinkman, MBeth, McLoughlin, M, Perez, C, Howell, JK, Weinstock, GM, Norris, SJ, Palzkill, T
JournalInfect Immun
Volume73
Issue7
Pagination4445-50
Date Published2005 Jul
ISSN0019-9567
KeywordsAnimals, Antibodies, Bacterial, Antigens, Bacterial, Genome, Bacterial, Proteome, Rabbits, Treponema pallidum
Abstract

Antibody responses for 882 of the 1,039 proteins in the proteome of Treponema pallidum were examined. Sera collected from infected rabbits were used to systematically identify 106 antigenic proteins, including 22 previously identified antigens and 84 novel antigens. Additionally, sera collected from rabbits throughout the course of infection demonstrated a progression in the breadth and intensity of humoral immunoreactivity against a representative panel of T. pallidum antigens.

DOI10.1128/IAI.73.7.4445-4450.2005
Alternate JournalInfect Immun
PubMed ID15972547
PubMed Central IDPMC1168556
Grant ListR01 AI045842 / AI / NIAID NIH HHS / United States
R03 AI069107 / AI / NIAID NIH HHS / United States
AI45842 / AI / NIAID NIH HHS / United States
AI49557 / AI / NIAID NIH HHS / United States

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