Genome scan for hypertension in nonobese African Americans: the National Heart, Lung, and Blood Institute Family Blood Pressure Program.

TitleGenome scan for hypertension in nonobese African Americans: the National Heart, Lung, and Blood Institute Family Blood Pressure Program.
Publication TypeJournal Article
Year of Publication2004
AuthorsMorrison, AC, Cooper, R, Hunt, S, Lewis, CE, Luke, A, Mosley, TH, Boerwinkle, E
JournalAm J Hypertens
Volume17
Issue9
Pagination834-8
Date Published2004 Sep
ISSN0895-7061
KeywordsAfrican Americans, Body Mass Index, Chromosomes, Human, Pair 2, Genome, Human, Humans, Hypertension, Lod Score, Obesity
Abstract

BACKGROUND: Obesity is an important risk factor for hypertension, but epidemiologic studies provide evidence for the development of hypertension independent of obesity. In addition, the search for hypertension susceptibility genes should prove more informative when applied to a homogeneous subset of patients, such as those that are not obese. For this reason, we sought to identify genomic regions influencing susceptibility to hypertension in a nonobese sample of hypertensive African American families.METHODS: A genome-wide linkage scan was performed in a sample of 275 African American hypertensive families containing two or more nonobese (body mass index, < or = 30 kg/m2) individuals recruited by Networks of the Family Blood Pressure Program (FBPP).RESULTS: The best evidence for linkage of hypertension among the FBPP African American families was found on chromosome 2 (log of the odds [LOD]= 3.59 at 230 cM). All other chromosomes contained LOD scores less than 2. The African American sibships from the GENOA Network appear to largely contribute to the evidence for linkage on chromosome 2 (LOD = 4.07 at 233 cM).CONCLUSIONS: Significant evidence for linkage to hypertension in nonobese African American families was identified on chromosome 2q. These results suggest the presence of genes influencing susceptibility to adiposity-independent hypertension.

DOI10.1016/j.amjhyper.2004.04.009
Alternate JournalAm. J. Hypertens.
PubMed ID15363828
Grant ListHL54457 / HL / NHLBI NIH HHS / United States
HL54463 / HL / NHLBI NIH HHS / United States
HL54464 / HL / NHLBI NIH HHS / United States
HL54466 / HL / NHLBI NIH HHS / United States
HL54471 / HL / NHLBI NIH HHS / United States
HL54472 / HL / NHLBI NIH HHS / United States
HL54473 / HL / NHLBI NIH HHS / United States
HL54481 / HL / NHLBI NIH HHS / United States
HL54485 / HL / NHLBI NIH HHS / United States
HL54495 / HL / NHLBI NIH HHS / United States
HL54496 / HL / NHLBI NIH HHS / United States
HL54497 / HL / NHLBI NIH HHS / United States
HL54504 / HL / NHLBI NIH HHS / United States
HL54508 / HL / NHLBI NIH HHS / United States
HL54509 / HL / NHLBI NIH HHS / United States
HL54512 / HL / NHLBI NIH HHS / United States
HL54526 / HL / NHLBI NIH HHS / United States
HL64777 / HL / NHLBI NIH HHS / United States