The genome sequence of taurine cattle: a window to ruminant biology and evolution.

TitleThe genome sequence of taurine cattle: a window to ruminant biology and evolution.
Publication TypeJournal Article
Year of Publication2009
AuthorsElsik, CG, Tellam, RL, Worley, KC, Gibbs, RA, Muzny, DM, Weinstock, GM, Adelson, DL, Eichler, EE, Elnitski, L, Guigó, R, Hamernik, DL, Kappes, SM, Lewin, HA, Lynn, DJ, Nicholas, FW, Reymond, A, Rijnkels, M, Skow, LC, Zdobnov, EM, Schook, L, Womack, J, Alioto, T, Antonarakis, SE, Astashyn, A, Chapple, CE, Chen, H-C, Chrast, J, Camara, F, Ermolaeva, O, Henrichsen, CN, Hlavina, W, Kapustin, Y, Kiryutin, B, Kitts, P, Kokocinski, F, Landrum, M, Maglott, D, Pruitt, K, Sapojnikov, V, Searle, SM, Solovyev, V, Souvorov, A, Ucla, C, Wyss, C, Anzola, JM, Gerlach, D, Elhaik, E, Graur, D, Reese, JT, Edgar, RC, McEwan, JC, Payne, GM, Raison, JM, Junier, T, Kriventseva, EV, Eyras, E, Plass, M, Donthu, R, Larkin, DM, Reecy, J, Yang, MQ, Chen, L, Cheng, Z, Chitko-McKown, CG, Liu, GE, Matukumalli, LK, Song, J, Zhu, B, Bradley, DG, Brinkman, FSL, Lau, LPL, Whiteside, MD, Walker, A, Wheeler, TT, Casey, T, J German, B, Lemay, DG, Maqbool, NJ, Molenaar, AJ, Seo, S, Stothard, P, Baldwin, CL, Baxter, R, Brinkmeyer-Langford, CL, Brown, WC, Childers, CP, Connelley, T, Ellis, SA, Fritz, K, Glass, EJ, Herzig, CTA, Iivanainen, A, Lahmers, KK, Bennett, AK, C Dickens, M, Gilbert, JGR, Hagen, DE, Salih, H, Aerts, J, Caetano, AR, Dalrymple, B, Garcia, JFernando, Gill, CA, Hiendleder, SG, Memili, E, Spurlock, D, Williams, JL, Alexander, L, Brownstein, MJ, Guan, L, Holt, RA, Jones, SJM, Marra, MA, Moore, R, Moore, SS, Roberts, A, Taniguchi, M, Waterman, RC, Chacko, J, Chandrabose, MM, Cree, A, Dao, MDiep, Dinh, HH, Gabisi, RAyiesha, Hines, S, Hume, J, Jhangiani, SN, Joshi, V, Kovar, CL, Lewis, LR, Liu, Y-S, Lopez, J, Morgan, MB, Nguyen, NBich, Okwuonu, GO, Ruiz, SJuana, Santibanez, J, Wright, RA, Buhay, C, Ding, Y, Dugan-Rocha, S, Herdandez, J, Holder, M, Sabo, A, Egan, A, Goodell, J, Wilczek-Boney, K, Fowler, GR, Hitchens, MEdward, Lozado, RJ, Moen, C, Steffen, D, Warren, JT, Zhang, J, Chiu, R, Schein, JE, K Durbin, J, Havlak, P, Jiang, H, Liu, Y, Qin, X, Ren, Y, Shen, Y, Song, H, Bell, SNicole, Davis, C, Johnson, AJolivet, Lee, S, Nazareth, LV, Patel, BMayurkumar, Pu, L-L, Vattathil, S, Williams, RLee, Curry, S, Hamilton, C, Sodergren, E, Wheeler, DA, Barris, W, Bennett, GL, Eggen, A, Green, RD, Harhay, GP, Hobbs, M, Jann, O, Keele, JW, Kent, MP, Lien, S, McKay, SD, McWilliam, S, Ratnakumar, A, Schnabel, RD, Smith, T, Snelling, WM, Sonstegard, TS, Stone, RT, Sugimoto, Y, Takasuga, A, Taylor, JF, Van Tassell, CP, Macneil, MD, Abatepaulo, ARR, Abbey, CA, Ahola, V, Almeida, IG, Amadio, AF, Anatriello, E, Bahadue, SM, Biase, FH, Boldt, CR, Carroll, JA, Carvalho, WA, Cervelatti, EP, Chacko, E, Chapin, JE, Cheng, Y, Choi, J, Colley, AJ, de Campos, TA, De Donato, M, Santos, IKF de Mir, de Oliveira, CJF, Deobald, H, Devinoy, E, Donohue, KE, Dovc, P, Eberlein, A, Fitzsimmons, CJ, Franzin, AM, Garcia, GR, Genini, S, Gladney, CJ, Grant, JR, Greaser, ML, Green, JA, Hadsell, DL, Hakimov, HA, Halgren, R, Harrow, JL, Hart, EA, Hastings, N, Hernandez, M, Hu, Z-L, Ingham, A, Iso-Touru, T, Jamis, C, Jensen, K, Kapetis, D, Kerr, T, Khalil, SS, Khatib, H, Kolbehdari, D, Kumar, CG, Kumar, D, Leach, R, Lee, JC-M, Li, C, Logan, KM, Malinverni, R, Marques, E, Martin, WF, Martins, NF, Maruyama, SR, Mazza, R, McLean, KL, Medrano, JF, Moreno, BT, Moré, DD, Muntean, CT, Nandakumar, HP, Nogueira, MFG, Olsaker, I, Pant, SD, Panzitta, F, Pastor, RCP, Poli, MA, Poslusny, N, Rachagani, S, Ranganathan, S, Razpet, A, Riggs, PK, Rincon, G, Rodriguez-Osorio, N, Rodriguez-Zas, SL, Romero, NE, Rosenwald, A, Sando, L, Schmutz, SM, Shen, L, Sherman, L, Southey, BR, Lutzow, YStrandberg, Sweedler, JV, Tammen, I, Telugu, BPrakash V, Urbanski, JM, Utsunomiya, YT, Verschoor, CP, Waardenberg, AJ, Wang, Z, Ward, R, Weikard, R, Welsh, TH, White, SN, Wilming, LG, Wunderlich, KR, Yang, J, Zhao, F-Q
Corporate Authors
JournalScience
Volume324
Issue5926
Pagination522-8
Date Published2009 Apr 24
ISSN1095-9203
KeywordsAlternative Splicing, Animals, Animals, Domestic, Biological Evolution, Cattle, Evolution, Molecular, Female, Genetic Variation, Genome, Humans, Male, MicroRNAs, Molecular Sequence Data, Proteins, Sequence Analysis, DNA, Species Specificity, Synteny
Abstract

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

DOI10.1126/science.1169588
Alternate JournalScience
PubMed ID19390049
PubMed Central IDPMC2943200
Grant ListP30 DA018310 / DA / NIDA NIH HHS / United States
U54 HG003273-05S1 / HG / NHGRI NIH HHS / United States
U54 HG003273-04S1 / HG / NHGRI NIH HHS / United States
BBS/B/13446 / / Biotechnology and Biological Sciences Research Council / United Kingdom
BBS/B/13438 / / Biotechnology and Biological Sciences Research Council / United Kingdom
U54 HG003273-05 / HG / NHGRI NIH HHS / United States
U54 HG003273 / HG / NHGRI NIH HHS / United States
U54 HG003273-05S2 / HG / NHGRI NIH HHS / United States
U54 HG003273-08 / HG / NHGRI NIH HHS / United States
U54 HG003273-04 / HG / NHGRI NIH HHS / United States
U54 HG003273-06S1 / HG / NHGRI NIH HHS / United States
077198 / / Wellcome Trust / United Kingdom
BB/D524040/2 / / Biotechnology and Biological Sciences Research Council / United Kingdom
U54 HG003273-07 / HG / NHGRI NIH HHS / United States
062023 / / Wellcome Trust / United Kingdom
U54 HG003273-06 / HG / NHGRI NIH HHS / United States
U54 HG003273-06S2 / HG / NHGRI NIH HHS / United States