| Title | The genome sequence of taurine cattle: a window to ruminant biology and evolution. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Elsik, CG, Tellam, RL, Worley, KC, Gibbs, RA, Muzny, DM, Weinstock, GM, Adelson, DL, Eichler, EE, Elnitski, L, Guigó, R, Hamernik, DL, Kappes, SM, Lewin, HA, Lynn, DJ, Nicholas, FW, Reymond, A, Rijnkels, M, Skow, LC, Zdobnov, EM, Schook, L, Womack, J, Alioto, T, Antonarakis, SE, Astashyn, A, Chapple, CE, Chen, H-C, Chrast, J, Camara, F, Ermolaeva, O, Henrichsen, CN, Hlavina, W, Kapustin, Y, Kiryutin, B, Kitts, P, Kokocinski, F, Landrum, M, Maglott, D, Pruitt, K, Sapojnikov, V, Searle, SM, Solovyev, V, Souvorov, A, Ucla, C, Wyss, C, Anzola, JM, Gerlach, D, Elhaik, E, Graur, D, Reese, JT, Edgar, RC, McEwan, JC, Payne, GM, Raison, JM, Junier, T, Kriventseva, EV, Eyras, E, Plass, M, Donthu, R, Larkin, DM, Reecy, J, Yang, MQ, Chen, L, Cheng, Z, Chitko-McKown, CG, Liu, GE, Matukumalli, LK, Song, J, Zhu, B, Bradley, DG, Brinkman, FSL, Lau, LPL, Whiteside, MD, Walker, A, Wheeler, TT, Casey, T, J German, B, Lemay, DG, Maqbool, NJ, Molenaar, AJ, Seo, S, Stothard, P, Baldwin, CL, Baxter, R, Brinkmeyer-Langford, CL, Brown, WC, Childers, CP, Connelley, T, Ellis, SA, Fritz, K, Glass, EJ, Herzig, CTA, Iivanainen, A, Lahmers, KK, Bennett, AK, C Dickens, M, Gilbert, JGR, Hagen, DE, Salih, H, Aerts, J, Caetano, AR, Dalrymple, B, Garcia, JFernando, Gill, CA, Hiendleder, SG, Memili, E, Spurlock, D, Williams, JL, Alexander, L, Brownstein, MJ, Guan, L, Holt, RA, Jones, SJM, Marra, MA, Moore, R, Moore, SS, Roberts, A, Taniguchi, M, Waterman, RC, Chacko, J, Chandrabose, MM, Cree, A, Dao, MDiep, Dinh, HH, Gabisi, RAyiesha, Hines, S, Hume, J, Jhangiani, SN, Joshi, V, Kovar, CL, Lewis, LR, Liu, Y-S, Lopez, J, Morgan, MB, Nguyen, NBich, Okwuonu, GO, Ruiz, SJuana, Santibanez, J, Wright, RA, Buhay, C, Ding, Y, Dugan-Rocha, S, Herdandez, J, Holder, M, Sabo, A, Egan, A, Goodell, J, Wilczek-Boney, K, Fowler, GR, Hitchens, MEdward, Lozado, RJ, Moen, C, Steffen, D, Warren, JT, Zhang, J, Chiu, R, Schein, JE, K Durbin, J, Havlak, P, Jiang, H, Liu, Y, Qin, X, Ren, Y, Shen, Y, Song, H, Bell, SNicole, Davis, C, Johnson, AJolivet, Lee, S, Nazareth, LV, Patel, BMayurkumar, Pu, L-L, Vattathil, S, Williams, RLee, Curry, S, Hamilton, C, Sodergren, E, Wheeler, DA, Barris, W, Bennett, GL, Eggen, A, Green, RD, Harhay, GP, Hobbs, M, Jann, O, Keele, JW, Kent, MP, Lien, S, McKay, SD, McWilliam, S, Ratnakumar, A, Schnabel, RD, Smith, T, Snelling, WM, Sonstegard, TS, Stone, RT, Sugimoto, Y, Takasuga, A, Taylor, JF, Van Tassell, CP, Macneil, MD, Abatepaulo, ARR, Abbey, CA, Ahola, V, Almeida, IG, Amadio, AF, Anatriello, E, Bahadue, SM, Biase, FH, Boldt, CR, Carroll, JA, Carvalho, WA, Cervelatti, EP, Chacko, E, Chapin, JE, Cheng, Y, Choi, J, Colley, AJ, de Campos, TA, De Donato, M, Santos, IKF de Mir, de Oliveira, CJF, Deobald, H, Devinoy, E, Donohue, KE, Dovc, P, Eberlein, A, Fitzsimmons, CJ, Franzin, AM, Garcia, GR, Genini, S, Gladney, CJ, Grant, JR, Greaser, ML, Green, JA, Hadsell, DL, Hakimov, HA, Halgren, R, Harrow, JL, Hart, EA, Hastings, N, Hernandez, M, Hu, Z-L, Ingham, A, Iso-Touru, T, Jamis, C, Jensen, K, Kapetis, D, Kerr, T, Khalil, SS, Khatib, H, Kolbehdari, D, Kumar, CG, Kumar, D, Leach, R, Lee, JC-M, Li, C, Logan, KM, Malinverni, R, Marques, E, Martin, WF, Martins, NF, Maruyama, SR, Mazza, R, McLean, KL, Medrano, JF, Moreno, BT, Moré, DD, Muntean, CT, Nandakumar, HP, Nogueira, MFG, Olsaker, I, Pant, SD, Panzitta, F, Pastor, RCP, Poli, MA, Poslusny, N, Rachagani, S, Ranganathan, S, Razpet, A, Riggs, PK, Rincon, G, Rodriguez-Osorio, N, Rodriguez-Zas, SL, Romero, NE, Rosenwald, A, Sando, L, Schmutz, SM, Shen, L, Sherman, L, Southey, BR, Lutzow, YStrandberg, Sweedler, JV, Tammen, I, Telugu, BPrakash V, Urbanski, JM, Utsunomiya, YT, Verschoor, CP, Waardenberg, AJ, Wang, Z, Ward, R, Weikard, R, Welsh, TH, White, SN, Wilming, LG, Wunderlich, KR, Yang, J, Zhao, F-Q |
| Corporate Authors | Bovine Genome Sequencing and Analysis Consortium |
| Journal | Science |
| Volume | 324 |
| Issue | 5926 |
| Pagination | 522-8 |
| Date Published | 2009 Apr 24 |
| ISSN | 1095-9203 |
| Keywords | Alternative Splicing, Animals, Animals, Domestic, Biological Evolution, Cattle, Evolution, Molecular, Female, Genetic Variation, Genome, Humans, Male, MicroRNAs, Molecular Sequence Data, Proteins, Sequence Analysis, DNA, Species Specificity, Synteny |
| Abstract | To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| DOI | 10.1126/science.1169588 |
| Alternate Journal | Science |
| PubMed ID | 19390049 |
| PubMed Central ID | PMC2943200 |
| Grant List | U54 HG003273-04S1 / HG / NHGRI NIH HHS / United States
U54 HG003273-05 / HG / NHGRI NIH HHS / United States
U54 HG003273 / HG / NHGRI NIH HHS / United States
U54 HG003273-05S2 / HG / NHGRI NIH HHS / United States
U54 HG003273-08 / HG / NHGRI NIH HHS / United States
U54 HG003273-06S1 / HG / NHGRI NIH HHS / United States
077198 / WT_ / Wellcome Trust / United Kingdom
BBS/B/13438 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
U54 HG003273-07 / HG / NHGRI NIH HHS / United States
062023 / WT_ / Wellcome Trust / United Kingdom
U54 HG003273-06 / HG / NHGRI NIH HHS / United States
U54 HG003273-06S2 / HG / NHGRI NIH HHS / United States
P30 DA018310 / DA / NIDA NIH HHS / United States
BBS/B/13446 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
U54 HG003273-05S1 / HG / NHGRI NIH HHS / United States
BB/D524040/2 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
U54 HG003273-04 / HG / NHGRI NIH HHS / United States |