The genome of the social amoeba Dictyostelium discoideum.

TitleThe genome of the social amoeba Dictyostelium discoideum.
Publication TypeJournal Article
Year of Publication2005
AuthorsEichinger, L, Pachebat, JA, Glöckner, G, Rajandream, M-A, Sucgang, R, Berriman, M, Song, J, Olsen, R, Szafranski, K, Xu, Q, Tunggal, B, Kummerfeld, S, Madera, M, Konfortov, BA, Rivero, F, Bankier, AT, Lehmann, R, Hamlin, N, Davies, R, Gaudet, P, Fey, P, Pilcher, K, Chen, G, Saunders, D, Sodergren, E, Davis, P, Kerhornou, A, Nie, X, Hall, N, Anjard, C, Hemphill, L, Bason, N, Farbrother, P, Desany, B, Just, E, Morio, T, Rost, R, Churcher, C, Cooper, J, Haydock, S, van Driessche, N, Cronin, A, Goodhead, I, Muzny, DM, Mourier, T, Pain, A, Lu, M, Harper, D, Lindsay, R, Hauser, H, James, K, Quiles, M, M Babu, M, Saito, T, Buchrieser, C, Wardroper, A, Felder, M, Thangavelu, M, Johnson, D, Knights, A, Loulseged, H, Mungall, K, Oliver, K, Price, C, Quail, MA, Urushihara, H, Hernandez, J, Rabbinowitsch, E, Steffen, D, Sanders, M, Ma, J, Kohara, Y, Sharp, S, Simmonds, M, Spiegler, S, Tivey, A, Sugano, S, White, B, Walker, D, Woodward, J, Winckler, T, Tanaka, Y, Shaulsky, G, Schleicher, M, Weinstock, G, Rosenthal, A, Cox, EC, Chisholm, RL, Gibbs, RA, Loomis, WF, Platzer, M, Kay, RR, Williams, J, Dear, PH, Noegel, AA, Barrell, B, Kuspa, A
JournalNature
Volume435
Issue7038
Pagination43-57
Date Published2005 May 05
ISSN1476-4687
KeywordsAnimals, ATP-Binding Cassette Transporters, Base Composition, Cell Adhesion, Cell Movement, Centromere, Conserved Sequence, Dictyostelium, DNA Transposable Elements, DNA, Ribosomal, Eukaryotic Cells, Gene Duplication, Gene Transfer, Horizontal, Genome, Genomics, Humans, Molecular Sequence Data, Phylogeny, Proteome, Protozoan Proteins, Repetitive Sequences, Nucleic Acid, RNA, Transfer, Sequence Analysis, DNA, Signal Transduction, Social Behavior, Telomere
Abstract

The social amoebae are exceptional in their ability to alternate between unicellular and multicellular forms. Here we describe the genome of the best-studied member of this group, Dictyostelium discoideum. The gene-dense chromosomes of this organism encode approximately 12,500 predicted proteins, a high proportion of which have long, repetitive amino acid tracts. There are many genes for polyketide synthases and ABC transporters, suggesting an extensive secondary metabolism for producing and exporting small molecules. The genome is rich in complex repeats, one class of which is clustered and may serve as centromeres. Partial copies of the extrachromosomal ribosomal DNA (rDNA) element are found at the ends of each chromosome, suggesting a novel telomere structure and the use of a common mechanism to maintain both the rDNA and chromosomal termini. A proteome-based phylogeny shows that the amoebozoa diverged from the animal-fungal lineage after the plant-animal split, but Dictyostelium seems to have retained more of the diversity of the ancestral genome than have plants, animals or fungi.

DOI10.1038/nature03481
Alternate JournalNature
PubMed ID15875012
PubMed Central IDPMC1352341
Grant ListR01 HD035925 / HD / NICHD NIH HHS / United States