Genome typing of nonhuman primate models: implications for biomedical research.

TitleGenome typing of nonhuman primate models: implications for biomedical research.
Publication TypeJournal Article
Year of Publication2014
AuthorsHaus, T, Ferguson, B, Rogers, J, Doxiadis, G, Certa, U, Rose, NJ, Teepe, R, Weinbauer, GF, Roos, C
JournalTrends Genet
Volume30
Issue11
Pagination482-7
Date Published2014 Nov
ISSN0168-9525
KeywordsAnimals, Biomedical Research, Disease Models, Animal, Genetic Variation, Genome-Wide Association Study, Genomics, Humans, Precision Medicine, Primates, Sequence Analysis, DNA
Abstract

The success of personalized medicine rests on understanding the genetic variation between individuals. Thus, as medical practice evolves and variation among individuals becomes a fundamental aspect of clinical medicine, a thorough consideration of the genetic and genomic information concerning the animals used as models in biomedical research also becomes critical. In particular, nonhuman primates (NHPs) offer great promise as models for many aspects of human health and disease. These are outbred species exhibiting substantial levels of genetic variation; however, understanding of the contribution of this variation to phenotypes is lagging behind in NHP species. Thus, there is a pivotal need to address this gap and define strategies for characterizing both genomic content and variability within primate models of human disease. Here, we discuss the current state of genomics of NHP models and offer guidelines for future work to ensure continued improvement and utility of this line of biomedical research.

DOI10.1016/j.tig.2014.05.004
Alternate JournalTrends Genet.
PubMed ID24954183