| Title | Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Keaton, JM, Kamali, Z, Xie, T, Vaez, A, Williams, A, Goleva, SB, Ani, A, Evangelou, E, Hellwege, JN, Yengo, L, Young, WJ, Traylor, M, Giri, A, Zheng, Z, Zeng, J, Chasman, DI, Morris, AP, Caulfield, MJ, Hwang, S-J, Kooner, JS, Conen, D, Attia, JR, Morrison, AC, Loos, RJF, Kristiansson, K, Schmidt, R, Hicks, AA, Pramstaller, PP, Nelson, CP, Samani, NJ, Risch, L, Gyllensten, U, Melander, O, Riese, H, Wilson, JF, Campbell, H, Rich, SS, Psaty, BM, Lu, Y, Rotter, JI, Guo, X, Rice, KM, Vollenweider, P, Sundström, J, Langenberg, C, Tobin, MD, Giedraitis, V, Luan, J'an, Tuomilehto, J, Kutalik, Z, Ripatti, S, Salomaa, V, Girotto, G, Trompet, S, J Jukema, W, van der Harst, P, Ridker, PM, Giulianini, F, Vitart, V, Goel, A, Watkins, H, Harris, SE, Deary, IJ, van der Most, PJ, Oldehinkel, AJ, Keavney, BD, Hayward, C, Campbell, A, Boehnke, M, Scott, LJ, Boutin, T, Mamasoula, C, Jarvelin, M-R, Peters, A, Gieger, C, Lakatta, EG, Cucca, F, Hui, J, Knekt, P, Enroth, S, de Borst, MH, Polasek, O, Concas, MPina, Catamo, E, Cocca, M, Li-Gao, R, Hofer, E, Schmidt, H, Spedicati, B, Waldenberger, M, Strachan, DP, Laan, M, Teumer, A, Dörr, M, Gudnason, V, Cook, JP, Ruggiero, D, Kolcic, I, Boerwinkle, E, Traglia, M, Lehtimäki, T, Raitakari, OT, Johnson, AD, Newton-Cheh, C, Brown, MJ, Dominiczak, AF, Sever, PJ, Poulter, N, Chambers, JC, Elosua, R, Siscovick, D, Esko, T, Metspalu, A, Strawbridge, RJ, Laakso, M, Hamsten, A, Hottenga, J-J, de Geus, E, Morris, AD, Palmer, CNA, Nolte, IM, Milaneschi, Y, Marten, J, Wright, A, Zeggini, E, Howson, JMM, O'Donnell, CJ, Spector, T, Nalls, MA, Simonsick, EM, Liu, Y, van Duijn, CM, Butterworth, AS, Danesh, JN, Menni, C, Wareham, NJ, Khaw, K-T, Sun, YV, Wilson, PWF, Cho, K, Visscher, PM, Denny, JC, Levy, D, Edwards, TL, Munroe, PB, Snieder, H, Warren, HR |
| Corporate Authors | Million Veteran Program, LifeLines Cohort Study, CHARGE Consortium, ICBP Consortium |
| Journal | Nat Genet |
| Volume | 56 |
| Issue | 5 |
| Pagination | 778-791 |
| Date Published | 2024 May |
| ISSN | 1546-1718 |
| Keywords | Blood Pressure, Female, Genetic Predisposition to Disease, Genetic Risk Score, Genome-Wide Association Study, Humans, Hypertension, Male, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Risk Factors |
| Abstract | Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P |
| DOI | 10.1038/s41588-024-01714-w |
| Alternate Journal | Nat Genet |
| PubMed ID | 38689001 |
| PubMed Central ID | PMC11096100 |
| Grant List | I01 BX004821 / BX / BLRD VA / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States |