A genomewide admixture map for Latino populations.

TitleA genomewide admixture map for Latino populations.
Publication TypeJournal Article
Year of Publication2007
AuthorsPrice, AL, Patterson, N, Yu, F, Cox, DR, Waliszewska, A, McDonald, GJ, Tandon, A, Schirmer, C, Neubauer, J, Bedoya, G, Duque, C, Villegas, A, Bortolini, MCatira, Salzano, FM, Gallo, C, Mazzotti, G, Tello-Ruiz, M, Riba, L, Aguilar-Salinas, CA, Canizales-Quinteros, S, Menjivar, M, Klitz, W, Henderson, B, Haiman, CA, Winkler, C, Tusie-Luna, T, Ruiz-Linares, A, Reich, D
JournalAm J Hum Genet
Volume80
Issue6
Pagination1024-36
Date Published2007 Jun
ISSN0002-9297
KeywordsAfrican Continental Ancestry Group, Alleles, Case-Control Studies, Chromosome Mapping, Chromosomes, Human, Computer Simulation, Databases, Genetic, European Continental Ancestry Group, Genetic Markers, Genetic Predisposition to Disease, Genetic Testing, Genetics, Population, Genome, Human, Hispanic Americans, Humans, Indians, North American, Reproducibility of Results
Abstract

Admixture mapping is an economical and powerful approach for localizing disease genes in populations of recently mixed ancestry and has proven successful in African Americans. The method holds equal promise for Latinos, who typically inherit a mix of European, Native American, and African ancestry. However, admixture mapping in Latinos has not been practical because of the lack of a map of ancestry-informative markers validated in Native American and other populations. To address this, we screened multiple databases, containing millions of markers, to identify 4,186 markers that were putatively informative for determining the ancestry of chromosomal segments in Latino populations. We experimentally validated each of these markers in at least 232 new Latino, European, Native American, and African samples, and we selected a subset of 1,649 markers to form an admixture map. An advantage of our strategy is that we focused our map on markers distinguishing Native American from other ancestries and restricted it to markers with very similar frequencies in Europeans and Africans, which decreased the number of markers needed and minimized the possibility of false disease associations. We evaluated the effectiveness of our map for localizing disease genes in four Latino populations from both North and South America.

DOI10.1086/518313
Alternate JournalAm. J. Hum. Genet.
PubMed ID17503322
PubMed Central IDPMC1867092
Grant List / / Intramural NIH HHS / United States
DK073818 / DK / NIDDK NIH HHS / United States
NS043538 / NS / NINDS NIH HHS / United States
R21 DK073818 / DK / NIDDK NIH HHS / United States
N01 CO12400 / CO / NCI NIH HHS / United States
U54 RR020278-01 / RR / NCRR NIH HHS / United States
N01CO12400 / CA / NCI NIH HHS / United States
F32 DK076277 / DK / NIDDK NIH HHS / United States
U54 RR020278 / RR / NCRR NIH HHS / United States
R01 NS043538 / NS / NINDS NIH HHS / United States