A genomewide linkage scan for quantitative trait loci influencing the craniofacial complex in baboons (Papio hamadryas spp.).

TitleA genomewide linkage scan for quantitative trait loci influencing the craniofacial complex in baboons (Papio hamadryas spp.).
Publication TypeJournal Article
Year of Publication2008
AuthorsSherwood, RJ, Duren, DL, Havill, LM, Rogers, J, Cox, LA, Towne, B, Mahaney, MC
JournalGenetics
Volume180
Issue1
Pagination619-28
Date Published2008 Sep
ISSN0016-6731
KeywordsAnimals, Anthropometry, Female, Genetic Linkage, Genetic Variation, Genome, Humans, Likelihood Functions, Male, Models, Biological, Models, Genetic, Papio hamadryas, Quantitative Trait Loci, Skull, Species Specificity
Abstract

Numerous studies have detected significant contributions of genes to variation in development, size, and shape of craniofacial traits in a number of vertebrate taxa. This study examines 43 quantitative traits derived from lateral cephalographs of 830 baboons (Papio hamadryas) from the pedigreed population housed at the Southwest National Primate Research Center. Quantitative genetic analyses were conducted using the SOLAR analytic platform, a maximum-likelihood variance components method that incorporates all familial information for parameter estimation. Heritability estimates were significant and of moderate to high magnitude for all craniofacial traits. Additionally, 14 significant quantitative trait loci (QTL) were identified for 12 traits from the three developmental components (basicranium, splanchnocranium, and neurocranium) of the craniofacial complex. These QTL were found on baboon chromosomes (and human orthologs) PHA1 (HSA1), PHA 2 (HSA3), PHA4 (HSA6), PHA11 (HSA12), PHA13 (HSA2), PHA16 (HSA17), and PHA17 (HSA13) (PHA, P. hamadryas; HSA, Homo sapiens). This study of the genetic architecture of the craniofacial complex in baboons provides the groundwork needed to establish the baboon as an animal model for the study of genetic and nongenetic influences on craniofacial variation.

DOI10.1534/genetics.108.090407
Alternate JournalGenetics
PubMed ID18757921
PubMed Central IDPMC2535711
Grant ListC06 RR017515 / RR / NCRR NIH HHS / United States
R21 DE016408 / DE / NIDCR NIH HHS / United States
R01 DE016692 / DE / NIDCR NIH HHS / United States
C06 RR013556 / RR / NCRR NIH HHS / United States
P01 HL028972 / HL / NHLBI NIH HHS / United States
P51 RR13986 / RR / NCRR NIH HHS / United States
R01 MH059490 / MH / NIMH NIH HHS / United States
R37 MH059490 / MH / NIMH NIH HHS / United States
P01HL28972 / HL / NHLBI NIH HHS / United States
DE016692 / DE / NIDCR NIH HHS / United States
C06 RR15456 / RR / NCRR NIH HHS / United States
C06 RR015456 / RR / NCRR NIH HHS / United States
MH059490 / MH / NIMH NIH HHS / United States
DE016408 / DE / NIDCR NIH HHS / United States
P51 RR013986 / RR / NCRR NIH HHS / United States