Genomic segmental polymorphisms in inbred mouse strains.

TitleGenomic segmental polymorphisms in inbred mouse strains.
Publication TypeJournal Article
Year of Publication2004
AuthorsLi, J, Jiang, T, Mao, J-H, Balmain, A, Peterson, L, Harris, C, Rao, PH, Havlak, P, Gibbs, RA, Cai, W-W
JournalNat Genet
Volume36
Issue9
Pagination952-4
Date Published2004 Sep
ISSN1061-4036
KeywordsAnimals, Base Sequence, Chromosomes, Artificial, Bacterial, Gene Dosage, In Situ Hybridization, Fluorescence, Mice, Mice, Inbred Strains, Polymorphism, Genetic
Abstract

By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.

DOI10.1038/ng1417
Alternate JournalNat. Genet.
PubMed ID15322544