Heritability of alveolar bone loss from periodontal disease in a baboon population: a pilot study.

TitleHeritability of alveolar bone loss from periodontal disease in a baboon population: a pilot study.
Publication TypeJournal Article
Year of Publication2011
AuthorsD Miley, D, Baumgartner, MH, Cheverud, JM, Roseman, CC, Rogers, J, McLeod, DE, Reyes, E, Hildebolt, CF
JournalJ Periodontol
Volume82
Issue4
Pagination575-80
Date Published2011 Apr
ISSN1943-3670
KeywordsAge Factors, Alveolar Bone Loss, Animals, Disease Models, Animal, Female, Genetic Predisposition to Disease, Male, Mandible, Papio, Periodontal Diseases, Pilot Projects
Abstract

BACKGROUND: Reports from studies of twins, disease aggregation in families, animal models for periodontal disease, and various genetic-analysis studies have determined that genetics plays a role in the susceptibility to periodontal disease. The purpose of this pilot study is to evaluate the effect of genetics on periodontal disease by evaluating the heritability of alveolar bone loss in a captive baboon population.METHODS: A collection of baboon skulls from a pedigreed colony (for which scientists and veterinarians maintain complete genealogic and veterinary records) was obtained from the Southwest National Primate Research Center, San Antonio, Texas and used in this pilot study. Measurements of alveolar bone loss were performed on 390 dry baboon skulls. A periodontal probe was used to measure alveolar bone loss. Maximum likelihood methods (designed to handle complex genealogies) were used to determine the heritability of alveolar bone loss. This software used known pedigrees in the captive baboon sample and tested the relationship between pairwise kinship and alveolar bone loss data to determine the heritability of alveolar bone loss from periodontal disease.RESULTS: Genetic data were available for 347 of the 390 specimens. Using age and sex as covariates, genetic analysis indicated a heritability of 35% (standard error = 20%; P = 0.01). Although gender was not a significant factor in periodontal disease (P = 0.96), age was highly significantly associated with periodontal disease (P <0.0001).CONCLUSIONS: In this pilot study, analysis of alveolar bone loss measurements from captive baboons indicates that bone loss increases with age and that a portion of periodontal disease risk may be caused by genetic variance. These findings provide evidence that periodontal disease is heritable in captive baboons and indicate that a larger, more-detailed study is warranted.

DOI10.1902/jop.2010.100189
Alternate JournalJ. Periodontol.
PubMed ID21043800
PubMed Central IDPMC3575216
Grant ListC06-R014578 / / PHS HHS / United States
P51-RR013986 / RR / NCRR NIH HHS / United States
C06-RR015456 / RR / NCRR NIH HHS / United States
C06 RR013556 / RR / NCRR NIH HHS / United States
C06 RR014578 / RR / NCRR NIH HHS / United States
P30 AR057235 / AR / NIAMS NIH HHS / United States
C06-RR013556 / RR / NCRR NIH HHS / United States
C06 RR015456 / RR / NCRR NIH HHS / United States
P51 RR013986 / RR / NCRR NIH HHS / United States