Identification of new members of a carbohydrate kinase-encoding gene family.

TitleIdentification of new members of a carbohydrate kinase-encoding gene family.
Publication TypeJournal Article
Year of Publication1995
AuthorsWorley, KC, King, KY, Chua, S, McCabe, ER, Smith, RF
JournalJ Comput Biol
Date Published1995 Fall
KeywordsAmino Acid Sequence, Animals, Caenorhabditis elegans, Carbohydrates, Conserved Sequence, Databases, Factual, Genes, Helminth, Glucokinase, Glycerol Kinase, Humans, Molecular Sequence Data, Multigene Family, Phosphotransferases (Alcohol Group Acceptor), Phylogeny, Sequence Alignment, Sequence Homology, Amino Acid, Software

In a sequence database search using the human glycerol kinase-encoding sequence (HUMGLYKINB) as a query, we identified six previously unidentified carbohydrate kinase sequences. Five of the six newly identified sequences appear to be known types of carbohydrate kinases, four are glycerol kinases and one is a gluconokinase. The sixth newly identified sequence, the Caenorhabditis elegans gene, CER08D7.7-CEF59B2.1, shows similarity to the family of carbohydrate kinases including other glycerol kinases, xylulokinases, gluconokinases, ribulokinases, rhamnulokinases, and fucokinases. A phylogenetic comparison of this newly identified Caenorhabditis elegans gene with the other members of the carbohydrate kinase family demonstrated that this sequence cannot be assigned to one of the known classes of carbohydrate kinases.

Alternate JournalJ Comput Biol
PubMed ID8521274
Grant ListT15 LM007093 / LM / NLM NIH HHS / United States
IT15LM07093-02 / LM / NLM NIH HHS / United States
IR01-HG00973-01 / HG / NHGRI NIH HHS / United States
P30-HG00210 / HG / NHGRI NIH HHS / United States

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