Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia.

TitleIdentification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia.
Publication TypeJournal Article
Year of Publication2005
AuthorsAl-Lamki, Z, Wali, YA, Wasifuddin, SM, Zachariah, M, Al-Mjeni, R, Li, C, Muralitharan, S, Al-Kharusi, K, Gunaratne, P, Peterson, L, Gibbs, RA, Gingras, M-C, Margolin, JF
JournalPediatr Hematol Oncol
Volume22
Issue7
Pagination629-43
Date Published2005 Oct-Nov
ISSN0888-0018
KeywordsAdolescent, Biomarkers, Tumor, Child, Child, Preschool, Female, Gene Expression Profiling, Gene Expression Regulation, Leukemic, Humans, Male, Neoplasm Proteins, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Predictive Value of Tests, Prognosis, Recurrence, Reverse Transcriptase Polymerase Chain Reaction, Risk Factors
Abstract

Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.

DOI10.1080/08880010500199069
Alternate JournalPediatr Hematol Oncol
PubMed ID16166056