| Title | Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Al-Lamki, Z, Wali, YA, Wasifuddin, SM, Zachariah, M, Al-Mjeni, R, Li, C, Muralitharan, S, Al-Kharusi, K, Gunaratne, P, Peterson, L, Gibbs, RA, Gingras, M-C, Margolin, JF |
| Journal | Pediatr Hematol Oncol |
| Volume | 22 |
| Issue | 7 |
| Pagination | 629-43 |
| Date Published | 2005 Oct-Nov |
| ISSN | 0888-0018 |
| Keywords | Adolescent, Biomarkers, Tumor, Child, Child, Preschool, Female, Gene Expression Profiling, Gene Expression Regulation, Leukemic, Humans, Male, Neoplasm Proteins, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Predictive Value of Tests, Prognosis, Recurrence, Reverse Transcriptase Polymerase Chain Reaction, Risk Factors |
| Abstract | Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.
|
| DOI | 10.1080/08880010500199069 |
| Alternate Journal | Pediatr Hematol Oncol |
| PubMed ID | 16166056 |