Title | Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Kelly, TN, Sun, X, He, KY, Brown, MR, Taliun, SAGagliano, Hellwege, JN, Irvin, MR, Mi, X, Brody, JA, Franceschini, N, Guo, X, Hwang, S-J, de Vries, PS, Gao, Y, Moscati, A, Nadkarni, GN, Yanek, LR, Elfassy, T, Smith, JA, Chung, R-H, Beitelshees, AL, Patki, A, Aslibekyan, S, Blobner, BM, Peralta, JM, Assimes, TL, Palmas, WR, Liu, C, Bress, AP, Huang, Z, Becker, LC, Hwa, C-M, O'Connell, JR, Carlson, JC, Warren, HR, Das, S, Giri, A, Martin, LW, W Johnson, C, Fox, ER, Bottinger, EP, Razavi, AC, Vaidya, D, Chuang, L-M, Chang, Y-PC, Naseri, T, Jain, D, Kang, HMin, Hung, AM, Srinivasasainagendra, V, Snively, BM, Gu, D, Montasser, ME, Reupena, M'aSefuiva, Heavner, BD, LeFaive, J, Hixson, JE, Rice, KM, Wang, FFei, Nielsen, JB, Huang, J, Khan, AT, Zhou, W, Nierenberg, JL, Laurie, CC, Armstrong, ND, Shi, M, Pan, Y, Stilp, AM, Emery, L, Wong, Q, Hawley, NL, Minster, RL, Curran, JE, Munroe, PB, Weeks, DE, North, KE, Tracy, RP, Kenny, EE, Shimbo, D, Chakravarti, A, Rich, SS, Reiner, AP, Blangero, J, Redline, S, Mitchell, BD, Rao, DC, Chen, Y-DIda, Kardia, SLR, Kaplan, RC, Mathias, RA, He, J, Psaty, BM, Fornage, M, Loos, RJF, Correa, A, Boerwinkle, E, Rotter, JI, Kooperberg, C, Edwards, TL, Abecasis, GR, Zhu, X, Levy, D, Arnett, DK, Morrison, AC |
Corporate Authors | Samoan Obesity, Lifestyle, and Genetic Adaptations Study (OLaGA) Group,‡ NHLBI Trans-Omics for Precision Medicine TOPMed) Consortium |
Journal | Hypertension |
Volume | 79 |
Issue | 8 |
Pagination | 1656-1667 |
Date Published | 2022 Aug |
ISSN | 1524-4563 |
Keywords | Blood Pressure, Genome-Wide Association Study, Genomics, Humans, Hypertension, Polymorphism, Single Nucleotide, Precision Medicine |
Abstract | BACKGROUND: The availability of whole-genome sequencing data in large studies has enabled the assessment of coding and noncoding variants across the allele frequency spectrum for their associations with blood pressure. METHODS: We conducted a multiancestry whole-genome sequencing analysis of blood pressure among 51 456 Trans-Omics for Precision Medicine and Centers for Common Disease Genomics program participants (stage-1). Stage-2 analyses leveraged array data from UK Biobank (N=383 145), Million Veteran Program (N=318 891), and Reasons for Geographic and Racial Differences in Stroke (N=10 643) participants, along with whole-exome sequencing data from UK Biobank (N=199 631) participants. RESULTS: Two blood pressure signals achieved genome-wide significance in meta-analyses of stage-1 and stage-2 single variant findings ( DISCUSSION: We report one promising but unconfirmed rare variant for blood pressure and, more importantly, contribute insights for future blood pressure sequencing studies. Our findings suggest promise of aggregate analyses to complement single variant analysis strategies and the need for larger, diverse samples, and family studies to enable robust rare variant identification. |
DOI | 10.1161/HYPERTENSIONAHA.122.19324 |
Alternate Journal | Hypertension |
PubMed ID | 35652341 |
PubMed Central ID | PMC9593435 |
Grant List | R01 HL104135 / HL / NHLBI NIH HHS / United States U01 HL054472 / HL / NHLBI NIH HHS / United States R01 HL071025 / HL / NHLBI NIH HHS / United States UL1 RR033176 / RR / NCRR NIH HHS / United States R01 HL112064 / HL / NHLBI NIH HHS / United States HHSN268201100037C / HL / NHLBI NIH HHS / United States U01 HG007417 / HG / NHGRI NIH HHS / United States MC_PC_17228 / MRC_ / Medical Research Council / United Kingdom HHSN268201300005C / HL / NHLBI NIH HHS / United States K01 HL133468 / HL / NHLBI NIH HHS / United States N01HC95160 / HL / NHLBI NIH HHS / United States R01 HL071251 / HL / NHLBI NIH HHS / United States R01 HL133040 / HL / NHLBI NIH HHS / United States R01 HL120393 / HL / NHLBI NIH HHS / United States R01 HL087698 / HL / NHLBI NIH HHS / United States R01 HL046380 / HL / NHLBI NIH HHS / United States U54 HG003067 / HG / NHGRI NIH HHS / United States R01 HL121007 / HL / NHLBI NIH HHS / United States R01 HL131136 / HL / NHLBI NIH HHS / United States R01 HL111249 / HL / NHLBI NIH HHS / United States R01 HL071259 / HL / NHLBI NIH HHS / United States U01 HL054527 / HL / NHLBI NIH HHS / United States N01HC95163 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States UL1 TR001079 / TR / NCATS NIH HHS / United States HHSN268201600018C / HL / NHLBI NIH HHS / United States R01 HL092577 / HL / NHLBI NIH HHS / United States UL1 TR001863 / TR / NCATS NIH HHS / United States R21 HL140385 / HL / NHLBI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States R01 HL087660 / HL / NHLBI NIH HHS / United States T32 CA112355 / CA / NCI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States U01 HL054509 / HL / NHLBI NIH HHS / United States N01HC95169 / HL / NHLBI NIH HHS / United States U01 HL120393 / HL / NHLBI NIH HHS / United States R01 DK117445 / DK / NIDDK NIH HHS / United States R01 HL113338 / HL / NHLBI NIH HHS / United States T32 CA160056 / CA / NCI NIH HHS / United States R01 HL071250 / HL / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States N01HC65236 / HL / NHLBI NIH HHS / United States R01 DK110113 / DK / NIDDK NIH HHS / United States N01HC65235 / HL / NHLBI NIH HHS / United States R01 DK107786 / DK / NIDDK NIH HHS / United States I01 CX001897 / CX / CSRD VA / United States N01HC95164 / HL / NHLBI NIH HHS / United States U54 HG003273 / HG / NHGRI NIH HHS / United States R01 HL136666 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC65234 / HL / NHLBI NIH HHS / United States N01HC95162 / HL / NHLBI NIH HHS / United States U01 HL054464 / HL / NHLBI NIH HHS / United States R01 HL119443 / HL / NHLBI NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States N01HC95168 / HL / NHLBI NIH HHS / United States R35 HL135818 / HL / NHLBI NIH HHS / United States R01 HL098433 / HL / NHLBI NIH HHS / United States U01 HL072524 / HL / NHLBI NIH HHS / United States N01HC65233 / HL / NHLBI NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States R01 HL071051 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States HHSN268201500015C / HL / NHLBI NIH HHS / United States U01 HL054457 / HL / NHLBI NIH HHS / United States N01HC95165 / HL / NHLBI NIH HHS / United States N01HC65237 / HL / NHLBI NIH HHS / United States HHSN268201500016C / HL / NHLBI NIH HHS / United States U01 NS041588 / NS / NINDS NIH HHS / United States N01HC95159 / HL / NHLBI NIH HHS / United States R56 HG010297 / HG / NHGRI NIH HHS / United States M01 RR000052 / RR / NCRR NIH HHS / United States N01HC95161 / HL / NHLBI NIH HHS / United States UL1 TR001420 / TR / NCATS NIH HHS / United States U01 HL054498 / HL / NHLBI NIH HHS / United States U01 HL072515 / HL / NHLBI NIH HHS / United States U01 HL072518 / HL / NHLBI NIH HHS / United States P20 GM109036 / GM / NIGMS NIH HHS / United States HHSN268201500014C / HL / NHLBI NIH HHS / United States K12 HD043483 / HD / NICHD NIH HHS / United States HHSN268201600001C / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States U01 HL072507 / HL / NHLBI NIH HHS / United States N01HC95167 / HL / NHLBI NIH HHS / United States R01 HL093093 / HL / NHLBI NIH HHS / United States R01 HL087263 / HL / NHLBI NIH HHS / United States R35 HL155466 / HL / NHLBI NIH HHS / United States I01 BX003360 / BX / BLRD VA / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States R01 HL071205 / HL / NHLBI NIH HHS / United States U01 HL054481 / HL / NHLBI NIH HHS / United States R01 MD012765 / MD / NIMHD NIH HHS / United States UL1 TR000040 / TR / NCATS NIH HHS / United States R01 HL157635 / HL / NHLBI NIH HHS / United States R21 HL121429 / HL / NHLBI NIH HHS / United States R01 HG007022 / HG / NHGRI NIH HHS / United States UM1 HG008898 / HG / NHGRI NIH HHS / United States R01 HL117626 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC95166 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States UL1 TR001881 / TR / NCATS NIH HHS / United States R01 HL090682 / HL / NHLBI NIH HHS / United States U24 HG008956 / HG / NHGRI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States U01 HL054495 / HL / NHLBI NIH HHS / United States R01 HL071258 / HL / NHLBI NIH HHS / United States R01 AG018728 / AG / NIA NIH HHS / United States R01 HL055673 / HL / NHLBI NIH HHS / United States U01 HL054473 / HL / NHLBI NIH HHS / United States MC_QA137853 / MRC_ / Medical Research Council / United Kingdom N01HC85081 / HL / NHLBI NIH HHS / United States UL1 TR003098 / TR / NCATS NIH HHS / United States R01 HL088119 / HL / NHLBI NIH HHS / United States |
Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.
Similar Publications
Single cell dual-omic atlas of the human developing retina. Nat Commun. 2024;15(1):6792. | .
Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy. Nat Commun. 2024;15(1):7239. | .
The DNA methylome of pediatric brain tumors appears shaped by structural variation and predicts survival. Nat Commun. 2024;15(1):6775. | .