Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.

TitleInteractions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.
Publication TypeJournal Article
Year of Publication2010
AuthorsNettleton, JA, McKeown, NM, Kanoni, S, Lemaitre, RN, Hivert, M-F, Ngwa, J, van Rooij, FJA, Sonestedt, E, Wojczynski, MK, Ye, Z, Tanaka, T, Garcia, M, Anderson, JS, Follis, JL, Djousse, L, Mukamal, K, Papoutsakis, C, Mozaffarian, D, M Zillikens, C, Bandinelli, S, Bennett, AJ, Borecki, IB, Feitosa, MF, Ferrucci, L, Forouhi, NG, Groves, CJ, Hallmans, G, Harris, T, Hofman, A, Houston, DK, Hu, FB, Johansson, I, Kritchevsky, SB, Langenberg, C, Launer, L, Liu, Y, Loos, RJ, Nalls, M, Orho-Melander, M, Renstrom, F, Rice, K, Riserus, U, Rolandsson, O, Rotter, JI, Saylor, G, Sijbrands, EJG, Sjogren, P, Smith, A, Steingrímsdóttir, L, Uitterlinden, AG, Wareham, NJ, Prokopenko, I, Pankow, JS, van Duijn, CM, Florez, JC, Witteman, JCM, Dupuis, J, Dedoussis, GV, Ordovas, JM, Ingelsson, E, L Cupples, A, Siscovick, DS, Franks, PW, Meigs, JB
Corporate AuthorsMAGIC Investigators
JournalDiabetes Care
Volume33
Issue12
Pagination2684-91
Date Published2010 Dec
ISSN1935-5548
KeywordsAdult, Aged, Blood Glucose, Edible Grain, European Continental Ancestry Group, Fasting, Female, Genetic Loci, Genome-Wide Association Study, Genotype, Humans, Insulin, Male, Middle Aged, Polymorphism, Single Nucleotide
Abstract

OBJECTIVE: Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin.RESEARCH DESIGN AND METHODS: Via meta-analysis of data from 14 cohorts comprising ∼ 48,000 participants of European descent, we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a P value <0.0028 (0.05 of 18 tests) as statistically significant.RESULTS: Greater whole-grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (β [95% CI] per 1-serving-greater whole-grain intake: -0.009 mmol/l glucose [-0.013 to -0.005], P < 0.0001 and -0.011 pmol/l [ln] insulin [-0.015 to -0.007], P = 0.0003). No interactions met our multiple testing-adjusted statistical significance threshold. The strongest SNP interaction with whole-grain intake was rs780094 (GCKR) for fasting insulin (P = 0.006), where greater whole-grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele.CONCLUSIONS: Our results support the favorable association of whole-grain intake with fasting glucose and insulin and suggest a potential interaction between variation in GCKR and whole-grain intake in influencing fasting insulin concentrations.

DOI10.2337/dc10-1150
Alternate JournalDiabetes Care
PubMed ID20693352
PubMed Central IDPMC2992213
Grant ListMC_UP_A620_1015 / / Medical Research Council / United Kingdom
MC_UP_A100_1003 / / Medical Research Council / United Kingdom
G19/35 / / Medical Research Council / United Kingdom
G0100222 / / Medical Research Council / United Kingdom
MC_U127561128 / / Medical Research Council / United Kingdom
G8802774 / / Medical Research Council / United Kingdom
G0902037 / / Medical Research Council / United Kingdom
R01 AG032098 / AG / NIA NIH HHS / United States
MC_U106179471 / / Medical Research Council / United Kingdom
G0701863 / / Medical Research Council / United Kingdom
MC_U106188470 / / Medical Research Council / United Kingdom
R01 HL087700 / HL / NHLBI NIH HHS / United States
RG/07/008/23674 / / British Heart Foundation / United Kingdom