|Title||It's more than stamp collecting: how genome sequencing can unify biological research.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Date Published||2015 Jul|
|Keywords||Animals, Evolution, Molecular, Genome, Genomics, High-Throughput Nucleotide Sequencing, Humans, Sequence Analysis, DNA|
The availability of reference genome sequences, especially the human reference, has revolutionized the study of biology. However, while the genomes of some species have been fully sequenced, a wide range of biological problems still cannot be effectively studied for lack of genome sequence information. Here, I identify neglected areas of biology and describe how both targeted species sequencing and more broad taxonomic surveys of the tree of life can address important biological questions. I enumerate the significant benefits that would accrue from sequencing a broader range of taxa, as well as discuss the technical advances in sequencing and assembly methods that would allow for wide-ranging application of whole-genome analysis. Finally, I suggest that in addition to 'big science' survey initiatives to sequence the tree of life, a modified infrastructure-funding paradigm would better support reference genome sequence generation for research communities most in need.
|Alternate Journal||Trends Genet.|
|PubMed Central ID||PMC4490122|
|Grant List||U54 HG003273 / HG / NHGRI NIH HHS / United States|
It's more than stamp collecting: how genome sequencing can unify biological research.
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