Lack of genetic linkage evidence for a trans-acting factor having a large effect on plasma lipoprotein[a] levels in African Americans.

TitleLack of genetic linkage evidence for a trans-acting factor having a large effect on plasma lipoprotein[a] levels in African Americans.
Publication TypeJournal Article
Year of Publication2003
AuthorsBarkley, RAnn, Brown, AC, Hanis, CL, Kardia, SL, Turner, ST, Boerwinkle, E
JournalJ Lipid Res
Volume44
Issue7
Pagination1301-5
Date Published2003 Jul
ISSN0022-2275
KeywordsAdult, African Americans, African Continental Ancestry Group, Aged, Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 14, Chromosomes, Human, Pair 19, European Continental Ancestry Group, Genetic Linkage, Humans, Lipoprotein(a), Lod Score, Lysophospholipids, Male, Middle Aged, Transcriptional Activation
Abstract

The distribution of plasma lipoprotein[a] (Lp[a]) concentrations, a risk factor for cardiovascular disease, varies greatly among racial groups, with African Americans having values that are shifted toward higher levels than those of whites. The underlying cause of this heterogeneity is unknown, but a role for "trans-acting" factors has been hypothesized. This study used genetic linkage analysis to localize genetic factors influencing Lp[a] levels in African Americans that were absent in other populations; linkage results were analyzed separately in non-Hispanic whites, Hispanic whites, and African Americans. As expected, all three samples showed highly significant linkage at the approximate location of the lysophosphatidic acid locus. The white populations also independently had regions of significant linkage on chromosome 19 (LOD 3.80) and suggestive linkage on chromosomes 12 (LOD 1.60), 14 (LOD 2.56), and 19 (LOD 2.52). No linkage evidence was found to support the hypothesis of another single gene with large effects specifically segregating in African Americans that may account for their elevated Lp[a] levels.

DOI10.1194/jlr.M300163-JLR200
Alternate JournalJ. Lipid Res.
PubMed ID12730294