| Title | Long HIV-1 incubation periods and dynamics of transmission within a family. |
| Publication Type | Journal Article |
| Year of Publication | 1990 |
| Authors | Burger, H, Belman, AL, Grimson, R, Kaell, A, Flaherty, K, Gulla, J, Gibbs, RA, Nguyun, PN, Weiser, B |
| Journal | Lancet |
| Volume | 336 |
| Issue | 8708 |
| Pagination | 134-6 |
| Date Published | 1990 Jul 21 |
| ISSN | 0140-6736 |
| Keywords | Acquired Immunodeficiency Syndrome, Adolescent, Adult, CD4-Positive T-Lymphocytes, Child, DNA, Viral, Family, Family Health, Female, HIV Antibodies, HIV Seropositivity, HIV-1, Humans, Leukocyte Count, Male, Sexual Behavior, Substance Abuse, Intravenous, Time Factors |
| Abstract | The incubation period of human immunodeficiency virus type 1 (HIV-1) infection was studied in a family of five in which vertical and heterosexual transmission occurred from one index case. This investigation documented incubation periods of longer than 12 years in a mother and her daughter; although neither has symptoms, both are definitely infected and have very low CD4(+)-lymphocyte counts. The study confirmed the predictions of incubation periods longer than 10 years in a small proportion of infected individuals. It provides evidence that vertically HIV-1-infected teenagers can be expected to appear in the population.
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| DOI | 10.1016/0140-6736(90)91657-v |
| Alternate Journal | Lancet |
| PubMed ID | 1973471 |
| Grant List | AI25893 / AI / NIAID NIH HHS / United States |