|Title||Long HIV-1 incubation periods and dynamics of transmission within a family.|
|Publication Type||Journal Article|
|Year of Publication||1990|
|Authors||Burger, H, Belman, AL, Grimson, R, Kaell, A, Flaherty, K, Gulla, J, Gibbs, RA, Nguyun, PN, Weiser, B|
|Date Published||1990 Jul 21|
|Keywords||Acquired Immunodeficiency Syndrome, Adolescent, Adult, CD4-Positive T-Lymphocytes, Child, DNA, Viral, Family, Family Health, Female, HIV Antibodies, HIV Seropositivity, HIV-1, Humans, Leukocyte Count, Male, Sexual Behavior, Substance Abuse, Intravenous, Time Factors|
The incubation period of human immunodeficiency virus type 1 (HIV-1) infection was studied in a family of five in which vertical and heterosexual transmission occurred from one index case. This investigation documented incubation periods of longer than 12 years in a mother and her daughter; although neither has symptoms, both are definitely infected and have very low CD4(+)-lymphocyte counts. The study confirmed the predictions of incubation periods longer than 10 years in a small proportion of infected individuals. It provides evidence that vertically HIV-1-infected teenagers can be expected to appear in the population.
|Grant List||AI25893 / AI / NIAID NIH HHS / United States|