Long HIV-1 incubation periods and dynamics of transmission within a family.

TitleLong HIV-1 incubation periods and dynamics of transmission within a family.
Publication TypeJournal Article
Year of Publication1990
AuthorsBurger, H, Belman, AL, Grimson, R, Kaell, A, Flaherty, K, Gulla, J, Gibbs, RA, Nguyun, PN, Weiser, B
JournalLancet
Volume336
Issue8708
Pagination134-6
Date Published1990 Jul 21
ISSN0140-6736
KeywordsAcquired Immunodeficiency Syndrome, Adolescent, Adult, CD4-Positive T-Lymphocytes, Child, DNA, Viral, Family, Family Health, Female, HIV Antibodies, HIV Seropositivity, HIV-1, Humans, Leukocyte Count, Male, Sexual Behavior, Substance Abuse, Intravenous, Time Factors
Abstract

The incubation period of human immunodeficiency virus type 1 (HIV-1) infection was studied in a family of five in which vertical and heterosexual transmission occurred from one index case. This investigation documented incubation periods of longer than 12 years in a mother and her daughter; although neither has symptoms, both are definitely infected and have very low CD4(+)-lymphocyte counts. The study confirmed the predictions of incubation periods longer than 10 years in a small proportion of infected individuals. It provides evidence that vertically HIV-1-infected teenagers can be expected to appear in the population.

Alternate JournalLancet
PubMed ID1973471
Grant ListAI25893 / AI / NIAID NIH HHS / United States