Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study.

TitleLongitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2008
AuthorsNettleton, JA, Volcik, KA, Demerath, EW, Boerwinkle, E, Folsom, AR
JournalAnn Epidemiol
Volume18
Issue11
Pagination842-6
Date Published2008 Nov
ISSN1873-2585
KeywordsAged, Angiopoietin-like 4 Protein, Angiopoietins, Atherosclerosis, Body Mass Index, Female, Humans, Longitudinal Studies, Male, Middle Aged, Risk Factors, Triglycerides, United States, Weight Gain
Abstract

PURPOSE: Allelic variation in the adipokine angiopoietin-like 4 gene (ANGPTL4[E40K]) has been cross-sectionally associated with triglycerides, but the effects of genotype, or the interaction between genotype and body weight, on longitudinal triglyceride change have not been studied.METHODS: Body weight, triglycerides, and ANGPTL4[E40K] genotype were determined at baseline (1987-1989) and at 3 follow-up exams (1990-1992, 1993-1995, 1996-1998) in 7,939 white ANGPTL4[E40K] G allele homozygotes and 344 A allele carriers. Changes in body weight and triglycerides were characterized as the difference between exam 4 and baseline measurements.RESULTS: ANGPTL4[E40K] A allele carriers had triglyceride concentrations that were 15 to 18 mg/dL lower than G allele homozygotes at all exams (P<0.0001). Triglycerides increased in both genotype groups over the 9-year period (+19.1+/-0.9 and +16.2+/-4.1 mg/dL in GG and GA/AA, respectively; P difference, 0.48). Weight gain was associated with increased triglycerides to a comparable degree in both genotype groups (+5.5+/-0.3 and +4.3+/-0.9 mg/dL per 2-kg increase in body weight in GG and GA/AA, respectively, p interaction=0.30).CONCLUSIONS: Differences in triglyceride concentrations between ANGPTL4[E40K] A allele carriers and G allele homozygotes are maintained over time, but the degree of increase in triglycerides was similar between groups and was not modified by body weight changes.

DOI10.1016/j.annepidem.2008.07.004
Alternate JournalAnn Epidemiol
PubMed ID18809343
PubMed Central IDPMC2582040
Grant ListN01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States