Making Use of Cancer Genomic Databases.

TitleMaking Use of Cancer Genomic Databases.
Publication TypeJournal Article
Year of Publication2018
AuthorsCreighton, CJ
JournalCurr Protoc Mol Biol
Date Published2018 Jan 16
KeywordsDatabases, Genetic, DNA Methylation, Gene Expression Regulation, Neoplastic, Genomics, Humans, Mutation, Neoplasms, Software

The vast amounts of genomic data now deposited in public repositories represent rich resources for cancer researchers. Large-scale genomics initiatives such as The Cancer Genome Atlas have made available data from multiple molecular profiling platforms (e.g., somatic mutation, RNA and protein expression, and DNA methylation) for the same set of over 10,000 human tumors. There has been much collective effort toward providing user-friendly software tools for biologists lacking computational skills to ask questions of large-scale genomic datasets. At the same time, there remains a clear need for skilled bioinformatics analysts to answer the types of questions that cannot easily be addressed using the public user-friendly software tools. This overview introduces the reader to the many resources available for working with cancer genomic databases. © 2018 by John Wiley & Sons, Inc.

Alternate JournalCurr Protoc Mol Biol
PubMed ID29337373
PubMed Central IDPMC5774229
Grant ListP30 CA125123 / CA / NCI NIH HHS / United States

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