Maternal and paternal age are jointly associated with childhood autism in Jamaica.

TitleMaternal and paternal age are jointly associated with childhood autism in Jamaica.
Publication TypeJournal Article
Year of Publication2012
AuthorsRahbar, MH, Samms-Vaughan, M, Loveland, KA, Pearson, DA, Bressler, J, Chen, Z, Ardjomand-Hessabi, M, Shakespeare-Pellington, S, Grove, ML, Beecher, C, Bloom, K, Boerwinkle, E
JournalJ Autism Dev Disord
Date Published2012 Sep
KeywordsAutistic Disorder, Child, Child, Preschool, Female, Humans, Infant, Jamaica, Male, Maternal Age, Paternal Age, Registries, Risk Factors

Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case-control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM.

Alternate JournalJ Autism Dev Disord
PubMed ID22230961
PubMed Central IDPMC3858006
Grant ListR01 ES022165 / ES / NIEHS NIH HHS / United States
R21 HD057808 / HD / NICHD NIH HHS / United States
UL1 RR024148 / RR / NCRR NIH HHS / United States
R21HD057808 / HD / NICHD NIH HHS / United States
UL1 TR000371 / TR / NCATS NIH HHS / United States

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