Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children.

TitleMaternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children.
Publication TypeJournal Article
Year of Publication2018
AuthorsChristian, MKA, Samms-Vaughan, M, Lee, MJ, Bressler, J, Hessabi, M, Grove, ML, Shakespeare-Pellington, S, Desai, CCoore, Reece, J-A, Loveland, KA, Boerwinkle, E, Rahbar, MH
JournalJ Autism Dev Disord
Date Published2018 08
KeywordsAdult, Autism Spectrum Disorder, Child, Communicable Diseases, Female, Humans, Jamaica, Male, Maternal Exposure, Pesticides, Pregnancy, Volatile Organic Compounds

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD.

Alternate JournalJ Autism Dev Disord
PubMed ID29549549
PubMed Central IDPMC6041149
Grant ListR21 HD057808 / HD / NICHD NIH HHS / United States
R21HD057808 / NH / NIH HHS / United States
R01 ES022165 / ES / NIEHS NIH HHS / United States
R01ES022165 / NH / NIH HHS / United States
UL1 TR000371 / TR / NCATS NIH HHS / United States