Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children.

TitleMaternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children.
Publication TypeJournal Article
Year of Publication2018
AuthorsChristian, MKA, Samms-Vaughan, M, Lee, MJ, Bressler, J, Hessabi, M, Grove, ML, Shakespeare-Pellington, S, Desai, CCoore, Reece, J-A, Loveland, KA, Boerwinkle, E, Rahbar, MH
JournalJ Autism Dev Disord
Date Published2018 Mar 16
ISSN1573-3432
Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD.

DOI10.1007/s10803-018-3537-6
Alternate JournalJ Autism Dev Disord
PubMed ID29549549
Grant ListR01 ES022165 / ES / NIEHS NIH HHS / United States
R21HD057808 / / National Institutes of Health /
R21 HD057808 / HD / NICHD NIH HHS / United States
UL1 TR000371 / / National Center for Research Resources /
R01ES022165 / / National Institutes of Health /