Metabolomics and Incidence of Atrial Fibrillation in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study.

TitleMetabolomics and Incidence of Atrial Fibrillation in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2015
AuthorsAlonso, A, Yu, B, Qureshi, WT, Grams, ME, Selvin, E, Soliman, EZ, Loehr, LR, Chen, LY, Agarwal, SK, Alexander, D, Boerwinkle, E
JournalPLoS One
Date Published2015
KeywordsAfrican Americans, Atherosclerosis, Atrial Fibrillation, Female, Humans, Incidence, Male, Metabolomics, Middle Aged, Residence Characteristics

BACKGROUND: Atrial fibrillation (AF) is a common arrhythmia. Application of metabolomic approaches, which may identify novel pathways and biomarkers of disease risk, to a longitudinal epidemiologic study of AF has been limited.

METHODS: We determined the prospective association of 118 serum metabolites identified through untargeted metabolomics profiling with the incidence of newly-diagnosed AF in 1919 African-American men and women from the Atherosclerosis Risk in Communities study without AF at baseline (1987-1989). Incident AF cases through 2011 were ascertained from study electrocardiograms, hospital discharge codes, and death certificates.

RESULTS: During a median follow-up of 22 years, we identified 183 incident AF cases. In Cox proportional hazards models adjusted for age, sex, smoking, body mass index, systolic blood pressure, use of antihypertensive medication, diabetes, prevalent heart failure, prevalent coronary heart disease, and kidney function, two conjugated bile acids (glycolithocholate sulfate and glycocholenate sulfate) were significantly associated with AF risk after correcting for multiple comparisons (p

CONCLUSION: We found an association of higher levels of two bile acids with an increased risk of AF, pointing to a potential novel pathway in AF pathogenesis. Replication of results in independent studies is warranted.

Alternate JournalPLoS ONE
PubMed ID26544570
PubMed Central IDPMC4636390
Grant ListK24DK106414 / DK / NIDDK NIH HHS / United States
RC1HL099452 / HL / NHLBI NIH HHS / United States
HSN268201100012C / / PHS HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100009C / / PHS HHS / United States
R01DK089174 / DK / NIDDK NIH HHS / United States
3U01HG004402-02S1 / HG / NHGRI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States