Title | Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Justice, AE, Chittoor, G, Gondalia, R, Melton, PE, Lim, E, Grove, ML, Whitsel, EA, Liu, C-T, L Cupples, A, Fernandez-Rhodes, L, Guan, W, Bressler, J, Fornage, M, Boerwinkle, E, Li, Y, Demerath, E, Heard-Costa, N, Levy, D, Stewart, JD, Baccarelli, A, Hou, L, Conneely, K, Mori, TA, Beilin, LJ, Huang, R-C, Gordon-Larsen, P, Howard, AGreen, North, KE |
Journal | Epigenomics |
Volume | 12 |
Issue | 17 |
Pagination | 1483-1499 |
Date Published | 2020 Sep |
ISSN | 1750-192X |
Abstract | We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820). We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near , , and that had not previously been associated with obesity-related traits. |
DOI | 10.2217/epi-2019-0276 |
Alternate Journal | Epigenomics |
PubMed ID | 32901515 |