Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.

TitleMethylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.
Publication TypeJournal Article
Year of Publication2020
AuthorsJustice, AE, Chittoor, G, Gondalia, R, Melton, PE, Lim, E, Grove, ML, Whitsel, EA, Liu, C-T, L Cupples, A, Fernandez-Rhodes, L, Guan, W, Bressler, J, Fornage, M, Boerwinkle, E, Li, Y, Demerath, E, Heard-Costa, N, Levy, D, Stewart, JD, Baccarelli, A, Hou, L, Conneely, K, Mori, TA, Beilin, LJ, Huang, R-C, Gordon-Larsen, P, Howard, AGreen, North, KE
JournalEpigenomics
Volume12
Issue17
Pagination1483-1499
Date Published2020 Sep
ISSN1750-192X
Abstract

We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820). We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near , ,  and that had not previously been associated with obesity-related traits.

DOI10.2217/epi-2019-0276
Alternate JournalEpigenomics
PubMed ID32901515