Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.

TitleMethylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.
Publication TypeJournal Article
Year of Publication2020
AuthorsJustice, AE, Chittoor, G, Gondalia, R, Melton, PE, Lim, E, Grove, ML, Whitsel, EA, Liu, C-T, L Cupples, A, Fernandez-Rhodes, L, Guan, W, Bressler, J, Fornage, M, Boerwinkle, E, Li, Y, Demerath, E, Heard-Costa, N, Levy, D, Stewart, JD, Baccarelli, A, Hou, L, Conneely, K, Mori, TA, Beilin, LJ, Huang, R-C, Gordon-Larsen, P, Howard, AGreen, North, KE
JournalEpigenomics
Volume12
Issue17
Pagination1483-1499
Date Published2020 Sep
ISSN1750-192X
KeywordsAdiposity, Cohort Studies, CpG Islands, Disease Susceptibility, DNA Methylation, Endocrine System, Epigenesis, Genetic, Epigenomics, Genome-Wide Association Study, Humans, Immune System, Obesity
Abstract

We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820). We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near , ,  and that had not previously been associated with obesity-related traits.
DOI10.2217/epi-2019-0276
Alternate JournalEpigenomics
PubMed ID32901515
PubMed Central IDPMC7923253
Grant ListRC2 HL102419 / HL / NHLBI NIH HHS / United States
K99 HL130580 / HL / NHLBI NIH HHS / United States
R01 HL143885 / HL / NHLBI NIH HHS / United States
HHSN268201600002C / HL / NHLBI NIH HHS / United States
R01 ES020836 / ES / NIEHS NIH HHS / United States
R01 HG009974 / HG / NHGRI NIH HHS / United States
R01 NS087541 / NS / NINDS NIH HHS / United States
R00 HL130580 / HL / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
HHSN268201700002C / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201500001I / HL / NHLBI NIH HHS / United States
HHSN268201600004C / HL / NHLBI NIH HHS / United States
HHSN268201600001C / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
HHSN268201500001C / HL / NHLBI NIH HHS / United States
HHSN268201600018C / HL / NHLBI NIH HHS / United States
HHSN268201600003C / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
HHSN268201700005C / HL / NHLBI NIH HHS / United States
HHSN268201700001C / HL / NHLBI NIH HHS / United States
HHSN268201700003C / HL / NHLBI NIH HHS / United States
75N92019D00031 / HL / NHLBI NIH HHS / United States
HHSN268201700004C / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
R01 HG010297 / HG / NHGRI NIH HHS / United States

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