| Title | Molecular characterization of 125I decay and X-ray-induced HPRT mutants in CHO cells. |
| Publication Type | Journal Article |
| Year of Publication | 1987 |
| Authors | Gibbs, RA, Camakaris, J, Hodgson, GS, Martin, RF |
| Journal | Int J Radiat Biol Relat Stud Phys Chem Med |
| Volume | 51 |
| Issue | 2 |
| Pagination | 193-9 |
| Date Published | 1987 Feb |
| ISSN | 0020-7616 |
| Keywords | Animals, Chromosome Deletion, Cricetinae, DNA Repair, Gamma Rays, Hypoxanthine Phosphoribosyltransferase, Iodine Radioisotopes, Mutation, Polymorphism, Restriction Fragment Length, X-Rays |
| Abstract | The predominant initial lesion induced by 125I decay in DNa is a double-strand DNA break comprising a 'mini deletion' of up to several base pairs (bp). However, Southern analysis of the structure of 125I decay-induced HPRT mutants in Chinese hamster ovary cells revealed that most of the mutants are deletions of thousands of bps. A similar predominance of substantial deletions was also found in X-ray-induced mutants.
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| DOI | 10.1080/09553008714550691 |
| Alternate Journal | Int J Radiat Biol Relat Stud Phys Chem Med |
| PubMed ID | 2881903 |