Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits.

TitleMulti-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits.
Publication TypeJournal Article
Year of Publication2021
AuthorsSun, D, Richard, M, Musani, SK, Sung, YJu, Winkler, TW, Schwander, K, Chai, JFang, Guo, X, Kilpeläinen, TO, Vojinovic, D, Aschard, H, Bartz, TM, Bielak, LF, Brown, MR, Chitrala, K, Hartwig, FP, Horimoto, ARVR, Liu, Y, Manning, AK, Noordam, R, Smith, AV, Harris, SE, Kühnel, B, Lyytikäinen, L-P, Nolte, IM, Rauramaa, R, van der Most, PJ, Wang, R, Ware, EB, Weiss, S, Wen, W, Yanek, LR, Arking, DE, Arnett, DK, Barac, A, Boerwinkle, E, Broeckel, U, Chakravarti, A, Chen, Y-DIda, L Cupples, A, Davigulus, ML, Fuentes, Lde Las, de Mutsert, R, de Vries, PS, Delaney, JAC, Roux, AVDiez, Dörr, M, Faul, JD, Fretts, AM, Gallo, LC, Grabe, HJörgen, C Gu, C, Harris, TB, Hartman, CCA, Heikkinen, S, M Ikram, A, Isasi, C, W Johnson, C, Jonas, JBruno, Kaplan, RC, Komulainen, P, Krieger, JE, Levy, D, Liu, J, Lohman, K, Luik, AI, Martin, LW, Meitinger, T, Milaneschi, Y, O'Connell, JR, Palmas, WR, Peters, A, Peyser, PA, Pulkki-Råback, L, Raffel, LJ, Reiner, AP, Rice, K, Robinson, JG, Rosendaal, FR, Schmidt, COliver, Schreiner, PJ, Schwettmann, L, Shikany, JM, Shu, X-O, Sidney, S, Sims, M, Smith, JA, Sotoodehnia, N, Strauch, K, E Tai, S, Taylor, K, Uitterlinden, AG, van Duijn, CM, Waldenberger, M, Wee, H-L, Bin Wei, W-, Wilson, G, Xuan, D, Yao, J, Zeng, D, Zhao, W, Zhu, X, Zonderman, AB, Becker, DM, Deary, IJ, Gieger, C, Lakka, TA, Lehtimäki, T, North, KE, Oldehinkel, AJ, Penninx, BWJH, Snieder, H, Wang, Y-X, Weir, DR, Zheng, W, Evans, MK, W Gauderman, J, Gudnason, V, Horta, BL, Liu, C-T, Mook-Kanamori, DO, Morrison, AC, Pereira, AC, Psaty, BM, Amin, N, Fox, ER, Kooperberg, C, Sim, X, Bierut, L, Rotter, JI, Kardia, SLR, Franceschini, N, Rao, DC, Fornage, M
Corporate AuthorsLifeLines Cohort Study
JournalHGG Adv
Volume2
Issue1
Date Published2021 Jan 14
ISSN2666-2477
Abstract

Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from 5 ancestry groups. In the combined meta-analyses of Stages 1 and 2, we identified 59 loci (p value

DOI10.1016/j.xhgg.2020.100013
Alternate JournalHGG Adv
PubMed ID34734193
PubMed Central IDPMC8562625
Grant ListR01 HL105756 / HL / NHLBI NIH HHS / United States
R01 HL118305 / HL / NHLBI NIH HHS / United States