Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.

TitleMulti-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
Publication TypeJournal Article
Year of Publication2021
AuthorsWang, H, Noordam, R, Cade, BE, Schwander, K, Winkler, TW, Lee, J, Sung, YJu, Bentley, AR, Manning, AK, Aschard, H, Kilpeläinen, TO, Ilkov, M, Brown, MR, Horimoto, AR, Richard, M, Bartz, TM, Vojinovic, D, Lim, E, Nierenberg, JL, Liu, Y, Chitrala, K, Rankinen, T, Musani, SK, Franceschini, N, Rauramaa, R, Alver, M, Zee, PC, Harris, SE, van der Most, PJ, Nolte, IM, Munroe, PB, Palmer, ND, Kühnel, B, Weiss, S, Wen, W, Hall, KA, Lyytikäinen, L-P, O'Connell, J, Eiriksdottir, G, Launer, LJ, de Vries, PS, Arking, DE, Chen, H, Boerwinkle, E, Krieger, JE, Schreiner, PJ, Sidney, S, Shikany, JM, Rice, K, Chen, Y-DIda, Gharib, SA, Bis, JC, Luik, AI, M Ikram, A, Uitterlinden, AG, Amin, N, Xu, H, Levy, D, He, J, Lohman, KK, Zonderman, AB, Rice, TK, Sims, M, Wilson, G, Sofer, T, Rich, SS, Palmas, W, Yao, J, Guo, X, Rotter, JI, Biermasz, NR, Mook-Kanamori, DO, Martin, LW, Barac, A, Wallace, RB, Gottlieb, DJ, Komulainen, P, Heikkinen, S, Mägi, R, Milani, L, Metspalu, A, Starr, JM, Milaneschi, Y, Waken, RJ, Gao, C, Waldenberger, M, Peters, A, Strauch, K, Meitinger, T, Roenneberg, T, Völker, U, Dörr, M, Shu, X-O, Mukherjee, S, Hillman, DR, Kähönen, M, Wagenknecht, LE, Gieger, C, Grabe, HJ, Zheng, W, Palmer, LJ, Lehtimäki, T, Gudnason, V, Morrison, AC, Pereira, AC, Fornage, M, Psaty, BM, van Duijn, CM, Liu, C-T, Kelly, TN, Evans, MK, Bouchard, C, Fox, ER, Kooperberg, C, Zhu, X, Lakka, TA, Esko, T, North, KE, Deary, IJ, Snieder, H, Penninx, BWJH, W Gauderman, J, Rao, DC, Redline, S, van Heemst, D
JournalMol Psychiatry
Volume26
Issue11
Pagination6293-6304
Date Published2021 11
ISSN1476-5578
KeywordsBlood Pressure, Genetic Loci, Genome-Wide Association Study, Humans, Hypertension, Polymorphism, Single Nucleotide, Sleep
Abstract

Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 P 

DOI10.1038/s41380-021-01087-0
Alternate JournalMol Psychiatry
PubMed ID33859359
PubMed Central IDPMC8517040
Grant ListR01-MD012765 / / U.S. Department of Health & Human Services | NIH | National Institute on Minority Health and Health Disparities (NIMHD) /
R21-HL140385 / / U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) /
ZIA HG200362 / ImNIH / Intramural NIH HHS / United States
P30 DK079626 / DK / NIDDK NIH HHS / United States
R35 HL135818 / HL / NHLBI NIH HHS / United States
R01 HL153814 / HL / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
R01 HL118305 / HL / NHLBI NIH HHS / United States
K01 HL135405 / HL / NHLBI NIH HHS / United States