| Title | Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Bentley, AR, Sung, YJ, Brown, MR, Winkler, TW, Kraja, AT, Ntalla, I, Schwander, K, Chasman, DI, Lim, E, Deng, X, Guo, X, Liu, J, Lu, Y, Cheng, C-Y, Sim, X, Vojinovic, D, Huffman, JE, Musani, SK, Li, C, Feitosa, MF, Richard, MA, Noordam, R, Baker, J, Chen, G, Aschard, H, Bartz, TM, Ding, J, Dorajoo, R, Manning, AK, Rankinen, T, Smith, AV, Tajuddin, SM, Zhao, W, Graff, M, Alver, M, Boissel, M, Chai, JFang, Chen, X, Divers, J, Evangelou, E, Gao, C, Goel, A, Hagemeijer, Y, Harris, SE, Hartwig, FP, He, M, Horimoto, ARVR, Hsu, F-C, Hung, Y-J, Jackson, AU, Kasturiratne, A, Komulainen, P, Kühnel, B, Leander, K, Lin, K-H, Luan, J'an, Lyytikäinen, L-P, Matoba, N, Nolte, IM, Pietzner, M, Prins, B, Riaz, M, Robino, A, M Said, A, Schupf, N, Scott, RA, Sofer, T, Stančáková, A, Takeuchi, F, Tayo, BO, van der Most, PJ, Varga, TV, Wang, T-D, Wang, Y, Ware, EB, Wen, W, Xiang, Y-B, Yanek, LR, Zhang, W, Zhao, JHua, Adeyemo, A, Afaq, S, Amin, N, Amini, M, Arking, DE, Arzumanyan, Z, Aung, T, Ballantyne, C, R Barr, G, Bielak, LF, Boerwinkle, E, Bottinger, EP, Broeckel, U, Brown, M, Cade, BE, Campbell, A, Canouil, M, Charumathi, S, Chen, Y-DIda, Christensen, K, Concas, MPina, Connell, JM, Fuentes, Lde Las, H de Silva, J, de Vries, PS, Doumatey, A, Duan, Q, Eaton, CB, Eppinga, RN, Faul, JD, Floyd, JS, Forouhi, NG, Forrester, T, Friedlander, Y, Gandin, I, Gao, H, Ghanbari, M, Gharib, SA, Gigante, B, Giulianini, F, Grabe, HJ, C Gu, C, Harris, TB, Heikkinen, S, Heng, C-K, Hirata, M, Hixson, JE, M Ikram, A, Jia, Y, Joehanes, R, Johnson, C, Jonas, JBruno, Justice, AE, Katsuya, T, Khor, CChuen, Kilpeläinen, TO, Koh, W-P, Kolcic, I, Kooperberg, C, Krieger, JE, Kritchevsky, SB, Kubo, M, Kuusisto, J, Lakka, TA, Langefeld, CD, Langenberg, C, Launer, LJ, Lehne, B, Lewis, CE, Li, Y, Liang, J, Lin, S, Liu, C-T, Liu, J, Liu, K, Loh, M, Lohman, KK, Louie, T, Luzzi, A, Mägi, R, Mahajan, A, Manichaikul, AW, McKenzie, CA, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mohlke, KL, Momozawa, Y, Morris, AP, Murray, AD, Nalls, MA, Nauck, M, Nelson, CP, North, KE, O'Connell, JR, Palmer, ND, Papanicolau, GJ, Pedersen, NL, Peters, A, Peyser, PA, Polasek, O, Poulter, N, Raitakari, OT, Reiner, AP, Renstrom, F, Rice, TK, Rich, SS, Robinson, JG, Rose, LM, Rosendaal, FR, Rudan, I, Schmidt, CO, Schreiner, PJ, Scott, WR, Sever, P, Shi, Y, Sidney, S, Sims, M, Smith, JA, Snieder, H, Starr, JM, Strauch, K, Stringham, HM, Tan, NYQ, Tang, H, Taylor, KD, Teo, YYing, Tham, YChung, Tiemeier, H, Turner, ST, Uitterlinden, AG, van Heemst, D, Waldenberger, M, Wang, H, Wang, L, Wang, L, Bin Wei, W, Williams, CA, Wilson, G, Wojczynski, MK, Yao, J, Young, K, Yu, C, Yuan, J-M, Zhou, J, Zonderman, AB, Becker, DM, Boehnke, M, Bowden, DW, Chambers, JC, Cooper, RS, de Faire, U, Deary, IJ, Elliott, P, Esko, T, Farrall, M, Franks, PW, Freedman, BI, Froguel, P, Gasparini, P, Gieger, C, Horta, BL, Juang, J-MJimmy, Kamatani, Y, Kammerer, CM, Kato, N, Kooner, JS, Laakso, M, Laurie, CC, Lee, I-T, Lehtimäki, T, Magnusson, PKE, Oldehinkel, AJ, Penninx, BWJH, Pereira, AC, Rauramaa, R, Redline, S, Samani, NJ, Scott, J, Shu, X-O, van der Harst, P, Wagenknecht, LE, Wang, J-S, Wang, YXing, Wareham, NJ, Watkins, H, Weir, DR, Wickremasinghe, AR, Wu, T, Zeggini, E, Zheng, W, Bouchard, C, Evans, MK, Gudnason, V, Kardia, SLR, Liu, Y, Psaty, BM, Ridker, PM, van Dam, RM, Mook-Kanamori, DO, Fornage, M, Province, MA, Kelly, TN, Fox, ER, Hayward, C, van Duijn, CM, E Tai, S, Wong, TYin, Loos, RJF, Franceschini, N, Rotter, JI, Zhu, X, Bierut, LJ, W Gauderman, J, Rice, K, Munroe, PB, Morrison, AC, Rao, DC, Rotimi, CN, L Cupples, A |
| Corporate Authors | COGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Society Scientific Group, Lifelines Cohort |
| Journal | Nat Genet |
| Volume | 51 |
| Issue | 4 |
| Pagination | 636-648 |
| Date Published | 2019 Apr |
| ISSN | 1546-1718 |
| Keywords | Adolescent, Adult, Aged, Aged, 80 and over, Female, Genome-Wide Association Study, Genotype, Humans, Life Style, Linkage Disequilibrium, Lipids, Male, Middle Aged, Smoking, Young Adult |
| Abstract | The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. |
| DOI | 10.1038/s41588-019-0378-y |
| Alternate Journal | Nat Genet |
| PubMed ID | 30926973 |
| PubMed Central ID | PMC6467258 |
| Grant List | R01 DK093757 / DK / NIDDK NIH HHS / United States P30 ES007048 / ES / NIEHS NIH HHS / United States U01 AG009740 / AG / NIA NIH HHS / United States Z01 HG200362 / ImNIH / Intramural NIH HHS / United States MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom R01 HL142302 / HL / NHLBI NIH HHS / United States MR/L01341X/1 / MRC_ / Medical Research Council / United Kingdom U01 AG023746 / AG / NIA NIH HHS / United States U01 CA182913 / CA / NCI NIH HHS / United States ZIA HG200362-02 / ImNIH / Intramural NIH HHS / United States BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom K01 HL135405 / HL / NHLBI NIH HHS / United States R01 HL120393 / HL / NHLBI NIH HHS / United States R01 HL046380 / HL / NHLBI NIH HHS / United States U01 HL120393 / HL / NHLBI NIH HHS / United States R01 HL113338 / HL / NHLBI NIH HHS / United States R01 DK117445 / DK / NIDDK NIH HHS / United States R01 DK072193 / DK / NIDDK NIH HHS / United States P30 DK079626 / DK / NIDDK NIH HHS / United States R01 DK107786 / DK / NIDDK NIH HHS / United States UM1 CA173640 / CA / NCI NIH HHS / United States R01 HL119443 / HL / NHLBI NIH HHS / United States R01 HL118305 / HL / NHLBI NIH HHS / United States R01 DK062370 / DK / NIDDK NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States R35 HL135818 / HL / NHLBI NIH HHS / United States MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom Z99 HG999999 / ImNIH / Intramural NIH HHS / United States MR/L01632X/1 / MRC_ / Medical Research Council / United Kingdom MR/K002414/1 / MRC_ / Medical Research Council / United Kingdom U01 HL137162 / HL / NHLBI NIH HHS / United States MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom U01 DK062370 / DK / NIDDK NIH HHS / United States MC_UP_1605/7 / MRC_ / Medical Research Council / United Kingdom R21 HL123677 / HL / NHLBI NIH HHS / United States P30 DK020572 / DK / NIDDK NIH HHS / United States R01 MD012765 / MD / NIMHD NIH HHS / United States UM1 CA182910 / CA / NCI NIH HHS / United States P2C HD050924 / HD / NICHD NIH HHS / United States |