Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

 
TitleMulti-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
Publication TypeJournal Article
Year of Publication2019
AuthorsBentley, AR, Sung, YJ, Brown, MR, Winkler, TW, Kraja, AT, Ntalla, I, Schwander, K, Chasman, DI, Lim, E, Deng, X, Guo, X, Liu, J, Lu, Y, Cheng, C-Y, Sim, X, Vojinovic, D, Huffman, JE, Musani, SK, Li, C, Feitosa, MF, Richard, MA, Noordam, R, Baker, J, Chen, G, Aschard, H, Bartz, TM, Ding, J, Dorajoo, R, Manning, AK, Rankinen, T, Smith, AV, Tajuddin, SM, Zhao, W, Graff, M, Alver, M, Boissel, M, Chai, JFang, Chen, X, Divers, J, Evangelou, E, Gao, C, Goel, A, Hagemeijer, Y, Harris, SE, Hartwig, FP, He, M, Horimoto, ARVR, Hsu, F-C, Hung, Y-J, Jackson, AU, Kasturiratne, A, Komulainen, P, Kühnel, B, Leander, K, Lin, K-H, Luan, J'an, Lyytikäinen, L-P, Matoba, N, Nolte, IM, Pietzner, M, Prins, B, Riaz, M, Robino, A, M Said, A, Schupf, N, Scott, RA, Sofer, T, Stančáková, A, Takeuchi, F, Tayo, BO, van der Most, PJ, Varga, TV, Wang, T-D, Wang, Y, Ware, EB, Wen, W, Xiang, Y-B, Yanek, LR, Zhang, W, Zhao, JHua, Adeyemo, A, Afaq, S, Amin, N, Amini, M, Arking, DE, Arzumanyan, Z, Aung, T, Ballantyne, C, R Barr, G, Bielak, LF, Boerwinkle, E, Bottinger, EP, Broeckel, U, Brown, M, Cade, BE, Campbell, A, Canouil, M, Charumathi, S, Chen, Y-DIda, Christensen, K, Concas, MPina, Connell, JM, Fuentes, Lde Las, H de Silva, J, de Vries, PS, Doumatey, A, Duan, Q, Eaton, CB, Eppinga, RN, Faul, JD, Floyd, JS, Forouhi, NG, Forrester, T, Friedlander, Y, Gandin, I, Gao, H, Ghanbari, M, Gharib, SA, Gigante, B, Giulianini, F, Grabe, HJ, C Gu, C, Harris, TB, Heikkinen, S, Heng, C-K, Hirata, M, Hixson, JE, M Ikram, A, Jia, Y, Joehanes, R, Johnson, C, Jonas, JBruno, Justice, AE, Katsuya, T, Khor, CChuen, Kilpeläinen, TO, Koh, W-P, Kolcic, I, Kooperberg, C, Krieger, JE, Kritchevsky, SB, Kubo, M, Kuusisto, J, Lakka, TA, Langefeld, CD, Langenberg, C, Launer, LJ, Lehne, B, Lewis, CE, Li, Y, Liang, J, Lin, S, Liu, C-T, Liu, J, Liu, K, Loh, M, Lohman, KK, Louie, T, Luzzi, A, Mägi, R, Mahajan, A, Manichaikul, AW, McKenzie, CA, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mohlke, KL, Momozawa, Y, Morris, AP, Murray, AD, Nalls, MA, Nauck, M, Nelson, CP, North, KE, O'Connell, JR, Palmer, ND, Papanicolau, GJ, Pedersen, NL, Peters, A, Peyser, PA, Polasek, O, Poulter, N, Raitakari, OT, Reiner, AP, Renstrom, F, Rice, TK, Rich, SS, Robinson, JG, Rose, LM, Rosendaal, FR, Rudan, I, Schmidt, CO, Schreiner, PJ, Scott, WR, Sever, P, Shi, Y, Sidney, S, Sims, M, Smith, JA, Snieder, H, Starr, JM, Strauch, K, Stringham, HM, Tan, NYQ, Tang, H, Taylor, KD, Teo, YYing, Tham, YChung, Tiemeier, H, Turner, ST, Uitterlinden, AG, van Heemst, D, Waldenberger, M, Wang, H, Wang, L, Wang, L, Bin Wei, W, Williams, CA, Wilson, G, Wojczynski, MK, Yao, J, Young, K, Yu, C, Yuan, J-M, Zhou, J, Zonderman, AB, Becker, DM, Boehnke, M, Bowden, DW, Chambers, JC, Cooper, RS, de Faire, U, Deary, IJ, Elliott, P, Esko, T, Farrall, M, Franks, PW, Freedman, BI, Froguel, P, Gasparini, P, Gieger, C, Horta, BL, Juang, J-MJimmy, Kamatani, Y, Kammerer, CM, Kato, N, Kooner, JS, Laakso, M, Laurie, CC, Lee, I-T, Lehtimäki, T, Magnusson, PKE, Oldehinkel, AJ, Penninx, BWJH, Pereira, AC, Rauramaa, R, Redline, S, Samani, NJ, Scott, J, Shu, X-O, van der Harst, P, Wagenknecht, LE, Wang, J-S, Wang, YXing, Wareham, NJ, Watkins, H, Weir, DR, Wickremasinghe, AR, Wu, T, Zeggini, E, Zheng, W, Bouchard, C, Evans, MK, Gudnason, V, Kardia, SLR, Liu, Y, Psaty, BM, Ridker, PM, van Dam, RM, Mook-Kanamori, DO, Fornage, M, Province, MA, Kelly, TN, Fox, ER, Hayward, C, van Duijn, CM, E Tai, S, Wong, TYin, Loos, RJF, Franceschini, N, Rotter, JI, Zhu, X, Bierut, LJ, W Gauderman, J, Rice, K, Munroe, PB, Morrison, AC, Rao, DC, Rotimi, CN, L Cupples, A
Corporate AuthorsCOGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Society Scientific Group, Lifelines Cohort
JournalNat Genet
Volume51
Issue4
Pagination636-648
Date Published2019 04
ISSN1546-1718
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Female, Genome-Wide Association Study, Genotype, Humans, Life Style, Linkage Disequilibrium, Lipids, Male, Middle Aged, Smoking, Young Adult
Abstract

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

DOI10.1038/s41588-019-0378-y
Alternate JournalNat. Genet.
PubMed ID30926973
PubMed Central IDPMC6467258
Grant ListU01 AG009740 / AG / NIA NIH HHS / United States
R01 DK117445 / DK / NIDDK NIH HHS / United States
MR/L01632X/1 / / Medical Research Council / United Kingdom
R01 HL142302 / HL / NHLBI NIH HHS / United States
R01 DK107786 / DK / NIDDK NIH HHS / United States
MR/L01341X/1 / / Medical Research Council / United Kingdom
R01 HL118305 / HL / NHLBI NIH HHS / United States
Z99 HG999999 / / Intramural NIH HHS / United States
R21 HL123677 / HL / NHLBI NIH HHS / United States
Z01 HG200362 / HG / NHGRI NIH HHS / United States
P30 DK020572 / DK / NIDDK NIH HHS / United States
R01 MD012765 / MD / NIMHD NIH HHS / United States
R01 HD057194 / HD / NICHD NIH HHS / United States
P2C HD050924 / HD / NICHD NIH HHS / United States
ZIA HG200362-02 / / Intramural NIH HHS / United States
K01 HL135405 / HL / NHLBI NIH HHS / United States