A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.

TitleA multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.
Publication TypeJournal Article
Year of Publication2019
AuthorsSung, YJu, Fuentes, Lde Las, Winkler, TW, Chasman, DI, Bentley, AR, Kraja, AT, Ntalla, I, Warren, HR, Guo, X, Schwander, K, Manning, AK, Brown, MR, Aschard, H, Feitosa, MF, Franceschini, N, Lu, Y, Cheng, C-Y, Sim, X, Vojinovic, D, Marten, J, Musani, SK, Kilpeläinen, TO, Richard, MA, Aslibekyan, S, Bartz, TM, Dorajoo, R, Li, C, Liu, Y, Rankinen, T, Smith, AVernon, Tajuddin, SM, Tayo, BO, Zhao, W, Zhou, Y, Matoba, N, Sofer, T, Alver, M, Amini, M, Boissel, M, Chai, JFang, Chen, X, Divers, J, Gandin, I, Gao, C, Giulianini, F, Goel, A, Harris, SE, Hartwig, FP, He, M, Horimoto, ARVR, Hsu, F-C, Jackson, AU, Kammerer, CM, Kasturiratne, A, Komulainen, P, Kühnel, B, Leander, K, Lee, W-J, Lin, K-H, Luan, J'an, Lyytikäinen, L-P, McKenzie, CA, Nelson, CP, Noordam, R, Scott, RA, Sheu, WHH, Stančáková, A, Takeuchi, F, van der Most, PJ, Varga, TV, Waken, RJ, Wang, H, Wang, Y, Ware, EB, Weiss, S, Wen, W, Yanek, LR, Zhang, W, Zhao, JHua, Afaq, S, Alfred, T, Amin, N, Arking, DE, Aung, T, R Barr, G, Bielak, LF, Boerwinkle, E, Bottinger, EP, Braund, PS, Brody, JA, Broeckel, U, Cade, B, Campbell, A, Canouil, M, Chakravarti, A, Cocca, M, Collins, FS, Connell, JM, de Mutsert, R, H de Silva, J, Dörr, M, Duan, Q, Eaton, CB, Ehret, G, Evangelou, E, Faul, JD, Forouhi, NG, Franco, OH, Friedlander, Y, Gao, H, Gigante, B, C Gu, C, Gupta, P, Hagenaars, SP, Harris, TB, He, J, Heikkinen, S, Heng, C-K, Hofman, A, Howard, BV, Hunt, SC, Irvin, MR, Jia, Y, Katsuya, T, Kaufman, J, Kerrison, ND, Khor, CChuen, Koh, W-P, Koistinen, HA, Kooperberg, CB, Krieger, JE, Kubo, M, Kutalik, Z, Kuusisto, J, Lakka, TA, Langefeld, CD, Langenberg, C, Launer, LJ, Lee, JH, Lehne, B, Levy, D, Lewis, CE, Li, Y, Lim, SHui, Liu, C-T, Liu, J, Liu, J, Liu, Y, Loh, M, Lohman, KK, Louie, T, Mägi, R, Matsuda, K, Meitinger, T, Metspalu, A, Milani, L, Momozawa, Y, Mosley, TH, Nalls, MA, Nasri, U, O'Connell, JR, Ogunniyi, A, Palmas, WR, Palmer, ND, Pankow, JS, Pedersen, NL, Peters, A, Peyser, PA, Polasek, O, Porteous, D, Raitakari, OT, Renstrom, F, Rice, TK, Ridker, PM, Robino, A, Robinson, JG, Rose, LM, Rudan, I, Sabanayagam, C, Salako, BL, Sandow, K, Schmidt, CO, Schreiner, PJ, Scott, WR, Sever, P, Sims, M, Sitlani, CM, Smith, BH, Smith, JA, Snieder, H, Starr, JM, Strauch, K, Tang, H, Taylor, KD, Teo, YYing, Tham, YChung, Uitterlinden, AG, Waldenberger, M, Wang, L, Wang, YXing, Bin Wei, W, Wilson, G, Wojczynski, MK, Xiang, Y-B, Yao, J, Yuan, J-M, Zonderman, AB, Becker, DM, Boehnke, M, Bowden, DW, Chambers, JC, Chen, Y-DIda, Weir, DR, de Faire, U, Deary, IJ, Esko, T, Farrall, M, Forrester, T, Freedman, BI, Froguel, P, Gasparini, P, Gieger, C, Horta, BLessa, Hung, Y-J, Jonas, JBruno, Kato, N, Kooner, JS, Laakso, M, Lehtimäki, T, Liang, K-W, Magnusson, PKE, Oldehinkel, AJ, Pereira, AC, Perls, T, Rauramaa, R, Redline, S, Rettig, R, Samani, NJ, Scott, J, Shu, X-O, van der Harst, P, Wagenknecht, LE, Wareham, NJ, Watkins, H, Wickremasinghe, AR, Wu, T, Kamatani, Y, Laurie, CC, Bouchard, C, Cooper, RS, Evans, MK, Gudnason, V, Hixson, J, Kardia, SLR, Kritchevsky, SB, Psaty, BM, van Dam, RM, Arnett, DK, Mook-Kanamori, DO, Fornage, M, Fox, ER, Hayward, C, van Duijn, CM, E Tai, S, Wong, TYin, Loos, RJF, Reiner, AP, Rotimi, CN, Bierut, LJ, Zhu, X, L Cupples, A, Province, MA, Rotter, JI, Franks, PW, Rice, K, Elliott, P, Caulfield, MJ, W Gauderman, J, Munroe, PB, Rao, DC, Morrison, AC
Corporate AuthorsLifeLines Cohort Study
JournalHum Mol Genet
Volume28
Issue15
Pagination2615-2633
Date Published2019 08 01
ISSN1460-2083
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Antiporters, Arterial Pressure, Blood Pressure, Caspase 9, Continental Population Groups, Ethnic Groups, Female, Gene-Environment Interaction, Genome-Wide Association Study, Humans, Hypertension, Male, Membrane Proteins, Middle Aged, Polymorphism, Genetic, Receptors, Vasopressin, Smoking, Sulfate Transporters, Tumor Suppressor Proteins, Young Adult
Abstract

Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene-smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene-smoking interaction analysis and 38 were newly identified (P 
DOI10.1093/hmg/ddz070
Alternate JournalHum Mol Genet
PubMed ID31127295
PubMed Central IDPMC6644157
Grant ListR01 HL103612 / HL / NHLBI NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States
MR/N003284/1 / MRC_ / Medical Research Council / United Kingdom
U01 HL120393 / HL / NHLBI NIH HHS / United States
14136 / CRUK_ / Cancer Research UK / United Kingdom
G0401527 / MRC_ / Medical Research Council / United Kingdom
MC_EX_MR/M009203/1 / MRC_ / Medical Research Council / United Kingdom
R01 AG055406 / AG / NIA NIH HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom
U01 AG023746 / AG / NIA NIH HHS / United States
BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
T32 DK091317 / DK / NIDDK NIH HHS / United States
MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom
G9521010 / MRC_ / Medical Research Council / United Kingdom
MR/K002414/1 / MRC_ / Medical Research Council / United Kingdom
R01 HL120393 / HL / NHLBI NIH HHS / United States
G0500300 / MRC_ / Medical Research Council / United Kingdom
U01 HL130114 / HL / NHLBI NIH HHS / United States
G1000143 / MRC_ / Medical Research Council / United Kingdom
MC_UP_1605/7 / MRC_ / Medical Research Council / United Kingdom
MC_PC_14089 / MRC_ / Medical Research Council / United Kingdom
K25 HL121091 / HL / NHLBI NIH HHS / United States
MR/M009203/1 / MRC_ / Medical Research Council / United Kingdom
MR/L01341X/1 / MRC_ / Medical Research Council / United Kingdom
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
R01 HL119443 / HL / NHLBI NIH HHS / United States
R01 HL118305 / HL / NHLBI NIH HHS / United States
R01 DK062370 / DK / NIDDK NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
FS/12/82/29736 / BHF_ / British Heart Foundation / United Kingdom
K01 HL135405 / HL / NHLBI NIH HHS / United States