Multiple genome alignment in the telomere-to-telomere assembly era.

TitleMultiple genome alignment in the telomere-to-telomere assembly era.
Publication TypeJournal Article
Year of Publication2022
AuthorsKille, B, Balaji, A, Sedlazeck, FJ, Nute, M, Treangen, TJ
JournalGenome Biol
Date Published2022 Aug 29
KeywordsGenome, Human, Genomics, Humans, Nucleotides, Telomere

With the arrival of telomere-to-telomere (T2T) assemblies of the human genome comes the computational challenge of efficiently and accurately constructing multiple genome alignments at an unprecedented scale. By identifying nucleotides across genomes which share a common ancestor, multiple genome alignments commonly serve as the bedrock for comparative genomics studies. In this review, we provide an overview of the algorithmic template that most multiple genome alignment methods follow. We also discuss prospective areas of improvement of multiple genome alignment for keeping up with continuously arriving high-quality T2T assembled genomes and for unlocking clinically-relevant insights.

Alternate JournalGenome Biol
PubMed ID36038949
PubMed Central IDPMC9421119
Grant ListP01 AI152999 / AI / NIAID NIH HHS / United States
T15 LM007093 / LM / NLM NIH HHS / United States

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