Oncodevelopmental and hormonal regulation of alpha 1-fetoprotein gene expression.

TitleOncodevelopmental and hormonal regulation of alpha 1-fetoprotein gene expression.
Publication TypeJournal Article
Year of Publication1983
AuthorsBélanger, L, Baril, P, Guertin, M, Gingras, M-C, Gourdeau, H, Anderson, A, Hamel, D, Boucher, JM
JournalAdv Enzyme Regul
Volume21
Pagination73-99
Date Published1983
ISSN0065-2571
KeywordsAlbumins, alpha-Fetoproteins, Animals, Base Sequence, Dexamethasone, DNA Replication, Gene Expression Regulation, Hormones, Humans, Liver, Medroxyprogesterone, Methionine, Oncogenes, Rats, RNA, Messenger, Transcription, Genetic
Abstract

The main features of the oncodevelopmental biology of alpha 1-fetoprotein (AFP) are reviewed. Progress made in the molecular biology of AFP gene regulation is discussed and we present our recent data on the mechanisms of AFP suppression by glucocorticoid hormones. The relationship between AFP gene transcription and cell replication is examined, and it is suggested that the degree of methylation of the AFP gene (or of co-methylated regulatory DNA sequences) conditions its response to hormones.

Alternate JournalAdv. Enzyme Regul.
PubMed ID6085825