Oncodevelopmental and hormonal regulation of alpha 1-fetoprotein gene expression.

TitleOncodevelopmental and hormonal regulation of alpha 1-fetoprotein gene expression.
Publication TypeJournal Article
Year of Publication1983
AuthorsBélanger, L, Baril, P, Guertin, M, Gingras, M-C, Gourdeau, H, Anderson, A, Hamel, D, Boucher, JM
JournalAdv Enzyme Regul
Date Published1983
KeywordsAlbumins, alpha-Fetoproteins, Animals, Base Sequence, Dexamethasone, DNA Replication, Gene Expression Regulation, Hormones, Humans, Liver, Medroxyprogesterone, Methionine, Oncogenes, Rats, RNA, Messenger, Transcription, Genetic

The main features of the oncodevelopmental biology of alpha 1-fetoprotein (AFP) are reviewed. Progress made in the molecular biology of AFP gene regulation is discussed and we present our recent data on the mechanisms of AFP suppression by glucocorticoid hormones. The relationship between AFP gene transcription and cell replication is examined, and it is suggested that the degree of methylation of the AFP gene (or of co-methylated regulatory DNA sequences) conditions its response to hormones.

Alternate JournalAdv Enzyme Regul
PubMed ID6085825

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