Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus.

TitlePas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus.
Publication TypeJournal Article
Year of Publication2005
AuthorsWang, M, Futamura, M, Wang, Y, You, M
Date Published2005 Mar 10
KeywordsAdenoma, Amino Acid Sequence, Animals, Base Sequence, DNA Primers, Exons, Genetic Predisposition to Disease, Lung Neoplasms, Mice, Molecular Sequence Data, Sequence Alignment, Sequence Homology, Amino Acid, Tumor Suppressor Proteins

Pas1 candidate 1 (Pas1c1) gene (also named Lmna-rs1) was found to encode two alternatively spliced mRNA transcripts (i.e. Pas1c1-Va and Pas1c1-Vb). In this study, we identified three additional mRNA transcripts encoded by the Pas1c1 gene, which were designated as Pas1c1-Vc, Pas1c1-Vd, and Pas1c1-Ve, respectively. Similar to Pas1c1-Vb, the newly identified transcripts were only expressed in mouse lung tissues from strains carrying the Pas1-susceptible (Pas1/s) allele. Pas1c1 transcripts were also detected in heart, testis, or brain but not in liver, spleen, or kidney. An 11-nucleotide polymorphism was found within the 3'-acceptor splice site of exon 8, which cosegregates with mouse strain Pas1 alleles and may underlie the strain-specific exon 8 skipping. We also found that ectopic expression of the Pas1c1-Va and Pas1c1-Vb in COS7 and NIH3T3 cells exhibited distinct intracellular distributions. These results support that Pas1c1 as a candidate for the Pas1 locus and the strain-specific isoforms may have differential effects on cell proliferation.

Alternate JournalOncogene
PubMed ID15688036
Grant ListR01CA58554 / CA / NCI NIH HHS / United States
R01ES012063 / ES / NIEHS NIH HHS / United States

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