Physical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study.

TitlePhysical Activity-Related Metabolites Are Associated with Mortality: Findings from the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2021
AuthorsXu, J, Liu, G, Hegde, SM, Palta, P, Boerwinkle, E, Gabriel, KP, Yu, B
JournalMetabolites
Volume11
Issue1
Date Published2021 Jan 19
ISSN2218-1989
Abstract

Habitual physical activity can diminish the risk of premature death. Identifying a pattern of metabolites related to physical activity may advance our understanding of disease etiology. We quantified 245 serum metabolites in 3802 participants from the Atherosclerosis Risk in Communities (ARIC) study using chromatography-mass spectrometry. We regressed self-reported moderate-to-vigorous intensity leisure-time physical activity (LTPA) against each metabolite, adjusting for traditional risk factors. A standardized metabolite risk score (MRS) was constructed to examine its association with all-cause mortality using the Cox proportional hazard model. We identified 10 metabolites associated with LTPA (

DOI10.3390/metabo11010059
Alternate JournalMetabolites
PubMed ID33477977
PubMed Central IDPMC7835806
Grant ListP30 DK079626 / DK / NIDDK NIH HHS / United States
P30 ES030285 / ES / NIEHS NIH HHS / United States
17SDG33661228 / / American Heart Association /