A physical map of the human genome.

TitleA physical map of the human genome.
Publication TypeJournal Article
Year of Publication2001
AuthorsMcPherson, JD, Marra, M, Hillier, L, Waterston, RH, Chinwalla, A, Wallis, J, Sekhon, M, Wylie, K, Mardis, ER, Wilson, RK, Fulton, R, Kucaba, TA, Wagner-McPherson, C, Barbazuk, WB, Gregory, SG, Humphray, SJ, French, L, Evans, RS, Bethel, G, Whittaker, A, Holden, JL, McCann, OT, Dunham, A, Soderlund, C, Scott, CE, Bentley, DR, Schuler, G, Chen, HC, Jang, W, Green, ED, Idol, JR, Maduro, VV, Montgomery, KT, Lee, E, Miller, A, Emerling, S, Gibbs, RA, Scherer, SE, Gorrell, JH, Sodergren, E, Clerc-Blankenburg, K, Tabor, P, Naylor, S, Garcia, D, de Jong, PJ, Catanese, JJ, Nowak, N, Osoegawa, K, Qin, S, Rowen, L, Madan, A, Dors, M, Hood, L, Trask, B, Friedman, C, Massa, H, Cheung, VG, Kirsch, IR, Reid, T, Yonescu, R, Weissenbach, J, Bruls, T, Heilig, R, Branscomb, E, Olsen, A, Doggett, N, Cheng, JF, Hawkins, T, Myers, RM, Shang, J, Ramirez, L, Schmutz, J, Velasquez, O, Dixon, K, Stone, NE, Cox, DR, Haussler, D, Kent, WJ, Furey, T, Rogic, S, Kennedy, S, Jones, S, Rosenthal, A, Wen, G, Schilhabel, M, Gloeckner, G, Nyakatura, G, Siebert, R, Schlegelberger, B, Korenberg, J, Chen, XN, Fujiyama, A, Hattori, M, Toyoda, A, Yada, T, Park, HS, Sakaki, Y, Shimizu, N, Asakawa, S, Kawasaki, K, Sasaki, T, Shintani, A, Shimizu, A, Shibuya, K, Kudoh, J, Minoshima, S, Ramser, J, Seranski, P, Hoff, C, Poustka, A, Reinhardt, R, Lehrach, H
Corporate Authors
JournalNature
Volume409
Issue6822
Pagination934-41
Date Published2001 Feb 15
ISSN0028-0836
KeywordsChromosomes, Artificial, Bacterial, Cloning, Molecular, Contig Mapping, DNA Fingerprinting, Gene Duplication, Genome, Human, Humans, In Situ Hybridization, Fluorescence, Repetitive Sequences, Nucleic Acid
Abstract

The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the accurate assembly of the genome sequence. Here we report the construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions. We also describe the integration of sequence data with the map.

DOI10.1038/35057157
Alternate JournalNature
PubMed ID11237014