Pleiotropic patterns of quantitative trait loci for 70 murine skeletal traits.

TitlePleiotropic patterns of quantitative trait loci for 70 murine skeletal traits.
Publication TypeJournal Article
Year of Publication2008
AuthorsKenney-Hunt, JP, Wang, B, Norgard, EA, Fawcett, G, Falk, D, L Pletscher, S, Jarvis, JP, Roseman, C, Wolf, J, Cheverud, JM
JournalGenetics
Volume178
Issue4
Pagination2275-88
Date Published2008 Apr
ISSN0016-6731
KeywordsAnimals, Bone and Bones, Chromosomes, Mammalian, Mice, Quantitative Trait Loci, Quantitative Trait, Heritable
Abstract

Quantitative trait locus (QTL) studies of a skeletal trait or a few related skeletal components are becoming commonplace, but as yet there has been no investigation of pleiotropic patterns throughout the skeleton. We present a comprehensive survey of pleiotropic patterns affecting mouse skeletal morphology in an intercross of LG/J and SM/J inbred strains (N = 1040), using QTL analysis on 70 skeletal traits. We identify 798 single-trait QTL, coalescing to 105 loci that affect on average 7-8 traits each. The number of traits affected per locus ranges from only 1 trait to 30 traits. Individual traits average 11 QTL each, ranging from 4 to 20. Skeletal traits are affected by many, small-effect loci. Significant additive genotypic values average 0.23 standard deviation (SD) units. Fifty percent of loci show codominance with heterozygotes having intermediate phenotypic values. When dominance does occur, the LG/J allele tends to be dominant to the SM/J allele (30% vs. 8%). Over- and underdominance are relatively rare (12%). Approximately one-fifth of QTL are sex specific, including many for pelvic traits. Evaluating the pleiotropic relationships of skeletal traits is important in understanding the role of genetic variation in the growth and development of the skeleton.

DOI10.1534/genetics.107.084434
Alternate JournalGenetics
PubMed ID18430949
PubMed Central IDPMC2323815
Grant List / / Biotechnology and Biological Sciences Research Council / United Kingdom
AR053224 / AR / NIAMS NIH HHS / United States
R01 AR053224 / AR / NIAMS NIH HHS / United States
DK055736 / DK / NIDDK NIH HHS / United States
BB/C516936/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom
R01 DK055736 / DK / NIDDK NIH HHS / United States
R56 DK055736 / DK / NIDDK NIH HHS / United States