Positive selection of a pre-expansion CAG repeat of the human SCA2 gene.

TitlePositive selection of a pre-expansion CAG repeat of the human SCA2 gene.
Publication TypeJournal Article
Year of Publication2005
AuthorsYu, F, Sabeti, PC, Hardenbol, P, Fu, Q, Fry, B, Lu, X, Ghose, S, Vega, R, Perez, A, Pasternak, S, Leal, SM, Willis, TD, Nelson, DL, Belmont, J, Gibbs, RA
JournalPLoS Genet
Date Published2005 Sep
KeywordsAtaxins, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 12, Europe, Exons, Gene Frequency, Humans, Molecular Sequence Data, Nerve Tissue Proteins, Polymorphism, Single Nucleotide, Selection, Genetic, Spinocerebellar Degenerations, Trinucleotide Repeats, Utah, White People

A region of approximately one megabase of human Chromosome 12 shows extensive linkage disequilibrium in Utah residents with ancestry from northern and western Europe. This strikingly large linkage disequilibrium block was analyzed with statistical and experimental methods to determine whether natural selection could be implicated in shaping the current genome structure. Extended Haplotype Homozygosity and Relative Extended Haplotype Homozygosity analyses on this region mapped a core region of the strongest conserved haplotype to the exon 1 of the Spinocerebellar ataxia type 2 gene (SCA2). Direct DNA sequencing of this region of the SCA2 gene revealed a significant association between a pre-expanded allele [(CAG)8CAA(CAG)4CAA(CAG)8] of CAG repeats within exon 1 and the selected haplotype of the SCA2 gene. A significantly negative Tajima's D value (-2.20, p < 0.01) on this site consistently suggested selection on the CAG repeat. This region was also investigated in the three other populations, none of which showed signs of selection. These results suggest that a recent positive selection of the pre-expansion SCA2 CAG repeat has occurred in Utah residents with European ancestry.

Alternate JournalPLoS Genet
PubMed ID16205789
PubMed Central IDPMC1239938
Grant ListU54 HG002755 / HG / NHGRI NIH HHS / United States
1U01 HG2755 / HG / NHGRI NIH HHS / United States

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