A preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high-sugar high-fat diet for 33 weeks.

TitleA preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high-sugar high-fat diet for 33 weeks.
Publication TypeJournal Article
Year of Publication2011
AuthorsMubiru, JN, Garcia-Forey, M, Higgins, PB, Hemmat, P, Cavazos, NE, Dick, EJ, Owston, MA, Bauer, CA, Shade, RE, Comuzzie, AG, Rogers, J
JournalJ Med Primatol
Volume40
Issue5
Pagination335-41
Date Published2011 Oct
ISSN1600-0684
KeywordsAbsorptiometry, Photon, Animals, Biomarkers, Blood Glucose, Body Composition, Body Weight, Cholesterol, Dietary Carbohydrates, Dietary Fats, Energy Metabolism, Insulin, Macaca fascicularis, Male, Metabolic Syndrome, Models, Animal, Triglycerides
Abstract

BACKGROUND: The metabolic syndrome is common in populations exposed to a typical Western diet. There is a lack of an animal model that mimics this condition.METHODS: We fed 15 cynomolgus monkeys ad libitum a high-sugar high-fat (HSHF) diet for 33 weeks. Body weight, body composition, serum lipids, and insulin were measured at baseline and at 33 weeks.RESULTS: The animals tolerated the HSHF diet very well. In the intervention group, total serum cholesterol and low-density lipoprotein cholesterol were 3- and 5-fold higher, respectively, at 33 weeks as compared with their baseline levels. Serum high-density lipoprotein cholesterol and triglycerides were not significantly affected. Dual-energy X-ray absorptiometry (DXA) analysis of the intervention group indicated that the trunk fat mass increased by 187% during this period.CONCLUSIONS: Cynomolgus monkeys should be a useful model for investigating the interactions of diet and other factors such as genetics in the development of the metabolic syndrome.

DOI10.1111/j.1600-0684.2011.00495.x
Alternate JournalJ. Med. Primatol.
PubMed ID21812784
PubMed Central IDPMC3282177
Grant ListK01 RR025161 / RR / NCRR NIH HHS / United States
K01 RR025161-02 / RR / NCRR NIH HHS / United States
K01 RR025161-03 / RR / NCRR NIH HHS / United States
K01RR025161-01 / RR / NCRR NIH HHS / United States
C06 RR013556 / RR / NCRR NIH HHS / United States
K01 OD010973 / OD / NIH HHS / United States
K01 RR025161-01A1 / RR / NCRR NIH HHS / United States
K01 OD010973-04 / OD / NIH HHS / United States
P51 RR0139986 / RR / NCRR NIH HHS / United States