Progress and prospects in rat genetics: a community view.

TitleProgress and prospects in rat genetics: a community view.
Publication TypeJournal Article
Year of Publication2008
AuthorsAitman, TJ, Critser, JK, Cuppen, E, Dominiczak, A, Fernandez-Suarez, XM, Flint, J, Gauguier, D, Geurts, AM, Gould, M, Harris, PC, Holmdahl, R, Hübner, N, Izsvák, Z, Jacob, HJ, Kuramoto, T, Kwitek, AE, Marrone, A, Mashimo, T, Moreno, C, Mullins, J, Mullins, L, Olsson, T, Pravenec, M, Riley, L, Saar, K, Serikawa, T, Shull, JD, Szpirer, C, Twigger, SN, Voigt, B, Worley, K
JournalNat Genet
Volume40
Issue5
Pagination516-22
Date Published2008 May
ISSN1546-1718
KeywordsAnimals, Animals, Genetically Modified, Chromosome Mapping, Disease Models, Animal, Gene Targeting, Genetic Diseases, Inborn, Genome, Genomics, Humans, Rats
Abstract

The rat is an important system for modeling human disease. Four years ago, the rich 150-year history of rat research was transformed by the sequencing of the rat genome, ushering in an era of exceptional opportunity for identifying genes and pathways underlying disease phenotypes. Genome-wide association studies in human populations have recently provided a direct approach for finding robust genetic associations in common diseases, but identifying the precise genes and their mechanisms of action remains problematic. In the context of significant progress in rat genomic resources over the past decade, we outline achievements in rat gene discovery to date, show how these findings have been translated to human disease, and document an increasing pace of discovery of new disease genes, pathways and mechanisms. Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research.

DOI10.1038/ng.147
Alternate JournalNat. Genet.
PubMed ID18443588
Grant ListMC_U120061454 / / Medical Research Council / United Kingdom
R01 CA077876 / CA / NCI NIH HHS / United States
U54 HG003273 / HG / NHGRI NIH HHS / United States